activation of naive (Th0) cells requires what?
IL-2
T/F: Th0 can become and T cell.
True
cytokines and functions of Th1
IFNg and TNFa activates macrophages and CTLs to kill INTRACELLULAR bacteria
cytokines and functions of Th2
IL-4 activates B cells to produce IgE for mast cells
-allergic response
cytokines and functions of Tfh
IL-21 helps B cells make high affinity Ab
cytokines and functions of Th17
IL-17 attracts neutrophils (bacteria/fungi)
cytokines and functions of Treg
IL-10, TGFb inhibits immune response
what drives Th differentiation?
dendritic cells and cytokines
can cytokine profiles differ between antigens?
yes
what is the role of TNFa?
induces apoptosis of infected cells
what is the role IFNg?
activate CD8+ T cells to become CTLs
what do macrophages secrete?
a chemokine (migration inhibition factor)
what does IL-5 recruit?
eosinophils
what is the role of IL-10?
down-regulates Th1 response
Th17 can lead to what?
-chronic inflammation or autoimmune disease