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Flashcards in naive T cell activation Deck (15)
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1
Q

activation of naive (Th0) cells requires what?

A

IL-2

2
Q

T/F: Th0 can become and T cell.

A

True

3
Q

cytokines and functions of Th1

A

IFNg and TNFa activates macrophages and CTLs to kill INTRACELLULAR bacteria

4
Q

cytokines and functions of Th2

A

IL-4 activates B cells to produce IgE for mast cells

-allergic response

5
Q

cytokines and functions of Tfh

A

IL-21 helps B cells make high affinity Ab

6
Q

cytokines and functions of Th17

A

IL-17 attracts neutrophils (bacteria/fungi)

7
Q

cytokines and functions of Treg

A

IL-10, TGFb inhibits immune response

8
Q

what drives Th differentiation?

A

dendritic cells and cytokines

9
Q

can cytokine profiles differ between antigens?

A

yes

10
Q

what is the role of TNFa?

A

induces apoptosis of infected cells

11
Q

what is the role IFNg?

A

activate CD8+ T cells to become CTLs

12
Q

what do macrophages secrete?

A

a chemokine (migration inhibition factor)

13
Q

what does IL-5 recruit?

A

eosinophils

14
Q

what is the role of IL-10?

A

down-regulates Th1 response

15
Q

Th17 can lead to what?

A

-chronic inflammation or autoimmune disease