Nausea and Labyrinth disorders Flashcards Preview

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Flashcards in Nausea and Labyrinth disorders Deck (29)
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1

Example of Phenothiazine that can be used in N&V

Prochlorperazine, trifluoperazine, perphenazine

2

How do the phenothiazine drugs work as an antiemetic?

Block the Chemoreceptor trigger zone

3

In terminal illness, what other antipsychotic drugs can be used?

Haloperidol and Levomopromazine

4

Which antiemetic is a prokinetic

Metoclopramide

5

Why is domperidone able to be used in parkinsons disease?

It does not cross the BBB so is less likely to cause sedation and dystonic reactions

6

Below what weight is domperidone unlicesned?

35kg

7

When is it appropriate to use Ondansetron/ Granisetron as antiemetics?

Post op (short term) or in chemotherpay N&V

8

what drug class is Netupitant?

Neurokinin 1 receptor antagonist

9

Examples of Neurokinin 1 receptor antagonists

Aprepitant, Netupitant, Fosaprepitant, Rolapitant

10

What are NK1 receptor antagonist drugs given alongisde?

Dexamethasone or a 5HT3 antagonist

11

Example of a synthetic cannabinoid

Nabilone

12

Which antiemeitc is used in pregnancy induced N&V

Promethazine, prochloperazine or metoclopramide

13

Risk factors of PONV

female, non smoker, history of PONV, motion sickness, intraoperative use of opioids

14

Which antiemetics are used to help with PONV

Ondanestron, cyclizine and prochlorperazine

15

Most effective drug for prevention of motion sickness

Hyoscine hydrobromide

16

If a sedative effect is required in motion sickness, what drug can be used?

Promethazine or a slighly less sedating antihistamine e.g Cyclizine, cinnarizine

17

Antiemetic licensed for vertigo. tinnitusd and hearing loss associated with Menierres disease?

Betahistadine

18

What age are cyclizine tablets not licensed for use?

<6 years

19

What age is domperidone contraindicated in

<12 years

20

Maximum duration of Domperidone and why?

7 days - due to cardiac side effects

21

What is the MHRA warning associated with Metoclopramide

neurological adverse effets e.g. Tardive Dyskinesia; max 10mg TDS 5 days `

22

IV metoclopramide should be given over how long?

slow bolus, 3 minutes

23

Can metoclopramide be given in Parkinsons or Epilepsy?

NO

24

Which patient group is most likely to experience adverse effects of Metoclopramide?

Very young and eldery

25

Caution wiht 5HT3 antagonists

QT prolongation

26

what is the MHRA alert regarding Ondansetron therapy in pregnacy?

Small increased risk of Cleft palate following use in first 12 weeks of pregnancy

27

What drug can cause anticholinergic syndrome (particularly in eldery)

Hyoscine hydrobromide

28

What are some symptoms of anticholinergic syndrome

Excitement, ataxia, hallucinations, behavioural abnormalities, drowsiness

29

Kwells and scopoderm are examples of what drug?

Hyoscine hydrobromide