Flashcards in Neonatal Isoerythrolysis Deck (15)
Which foals most commonly develop isoerythrolysis?
Foals born to multiparous mares
When does isoerythrolysis occur in a foal?
<7d (typically 2-3d)
What are the most common erythrocyte antigens implicated in neonatal isoerythrolysis?
Aa and Qa
What is neonatal isoerythrolysis?
Type 2 HS between RBC antigens of foal and antibodies of the mare that are ingested with colostrum
Where are neonatal isoerythrolysis antigens inherited?
From the sire
Why do mule foals have a higher incidence of neonatal isoerythrolysis?
"Donkey factor" RBC antigen
How is a mare first exposed to foreign RBC antigens in order to produce the antibodies that cause neonatal isoerythrolysis?
Blood transfusion, exposure to fetal blood
What are the three things that must be present for a foal to develop neonatal isoerythrolysis?
1. Foal RBC antigen inherited from sire
2. Maternal antibodies against foal RBC antigen
3. Neonatal ingestion of colostrum
What are clinical signs of neonatal isoerythrolysis?
Tachycardia, tachypnea/dyspnea, icterus, lethargy
What clinicopathologic changes support a diagnosis of neonatal isoerythrolysis?
Hyperbilirubinemia and anemia
What blood test do you do to dx neonatal isoerythrolysis?
Jaundice foal agglutination test
What is a jaundice foal agglutination test?
See if agglutination occurs between foal RBCs and mare's colostrum
How do you treat neonatal isoerythrolysis if the foal is <24h old?
Provide alternate source of milk and passive transfer
How do you treat a neonatal isoerythrolysis if the foal is >24h old?
Monitor PCV and rate of decline