Neoplasia

Question 1

Carcinoma that is marked by production of keratin

Answer 1

Squamous cell carcinoma

Question 2

Carcinoma in urinary tract

Answer 2

Transitional cell carcinoma

Question 3

Carcinoma in glandular epithelium

Answer 3

Adenocarcinoma

Question 4

Usually associated with adenocarcinoma and is the tumor-induced proliferation of non-neoplastic fibrous connective tissue

Answer 4

Desmoplasia

Most common the adenocarcinoma of breast, pancreas and prostate

Question 5

Malignant tumor of mesenchymal origin

Answer 5

Sarcoma

Question 6

Neoplasm derived from all the three germ cell layers

Answer 6

Teratoma

Usually arises from ovaries and testes

Question 7

Which is often encapsulated? Benign or malignant

Answer 7

Benign

Question 8

Benign neoplasm that arises from surface epithelium and consist delicate fingerlike epithelial processes

Answer 8

Papilloma

Question 9

Benign neoplasm of glandular epithelium

Answer 9

Adenoma

Question 10

Benign neoplasm that is characterized by adenomatous papillary processes that extend into cystic spaces

Answer 10

Papillary cystadenoma

As in cystadenoma of ovary

Question 11

Benign neoplasm that is marked by proliferation of connective tissue surrounding glandular epithelium

Answer 11

Fibroadenoma

Eg. Fibroadenoma of the breast

Question 12

Most common neoplasm in women

Answer 12

Uterine leiomyoma or fibroid tumor

Question 13

Small non neoplastic area of normal tissue misplaced withon another organ

Answer 13

Choristoma

Question 14

T or F: Most neoplasms are polyclonal

Answer 14

False. Most are monoclonal. Polyclonal proliferations are almost always non-neoplastic

Question 15

Most common marker used to determine clonality

Answer 15

Human Androgen Receptor Gene (HUMARA)

Question 16

Aggressive infiltration of adjacent tissues by malignant tumor

Answer 16

Invasion

Extends into lymphatics and blood vessels

Question 17

T or F: Presence of tumor cells within the blood vessels or lymphativs indicates metastasis

Answer 17

False. Indicates only penetration of the basement membrane or invasion

Question 18

Malignancy that has a characteristic cannon ball appearance on CXR

Answer 18

Metastasis to the Lung

Question 19

Preferential route of metastasis of carcinomas

Answer 19

Lymphatic

Question 20

Preferential route of metastasis of sarcomas

Answer 20

Hematogenous

Question 21

2 carcinomas that spread via hematogenous dissemination

Answer 21

Renal cell carcinoma and hepotocellular CA

Question 22

Responsible for the cachexia and wasting in malignancy

Answer 22

TNF-a or cachectin

Question 23

Cushing sundrome is a paraneoplastic syndrome of what malignancy

Answer 23

Small cell (oat cell) carcinoma of the lung

Production of ACTH-like substances

Question 24

Inappropriate secretion of ADH is a paraneoplastic syndrome of what malignancy

Answer 24

Small cell carcinoma of the lung

Question 25

Paraneoplastic syndrome characterized by sudden appearance of multiple seborrheic keratoses

Answer 25

Leser-Trelat sign

Question 26

Converts B-naphthylamine glucuronide to the carcinogenic B-naphthylamine

Answer 26

Mucosal glucuronidase Example of indirect-reacting carcinogens

Question 27

Malignancy obtained from excess sun exposure

Answer 27

Squamous cell carcinoma and basal cell carcinoma of skin; melanoma Due to induction of thymine dimers

Question 28

Malignancy resulting from alkylating agents

Answer 28

Acute leukemia