Neoplasia Flashcards Preview

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Flashcards in Neoplasia Deck (28):
1

Carcinoma that is marked by production of keratin

Squamous cell carcinoma

2

Carcinoma in urinary tract

Transitional cell carcinoma

3

Carcinoma in glandular epithelium

Adenocarcinoma

4

Usually associated with adenocarcinoma and is the tumor-induced proliferation of non-neoplastic fibrous connective tissue

Desmoplasia


Most common the adenocarcinoma of breast, pancreas and prostate

5

Malignant tumor of mesenchymal origin

Sarcoma

6

Neoplasm derived from all the three germ cell layers

Teratoma


Usually arises from ovaries and testes

7

Which is often encapsulated? Benign or malignant

Benign

8

Benign neoplasm that arises from surface epithelium and consist delicate fingerlike epithelial processes

Papilloma

9

Benign neoplasm of glandular epithelium

Adenoma

10

Benign neoplasm that is characterized by adenomatous papillary processes that extend into cystic spaces

Papillary cystadenoma



As in cystadenoma of ovary

11

Benign neoplasm that is marked by proliferation of connective tissue surrounding glandular epithelium

Fibroadenoma


Eg. Fibroadenoma of the breast

12

Most common neoplasm in women

Uterine leiomyoma or fibroid tumor

13

Small non neoplastic area of normal tissue misplaced withon another organ

Choristoma

14

T or F: Most neoplasms are polyclonal

False. Most are monoclonal. Polyclonal proliferations are almost always non-neoplastic

15

Most common marker used to determine clonality

Human Androgen Receptor Gene (HUMARA)

16

Aggressive infiltration of adjacent tissues by malignant tumor

Invasion


(Extends into lymphatics and blood vessels)

17

T or F: Presence of tumor cells within the blood vessels or lymphativs indicates metastasis

False. Indicates only penetration of the basement membrane or invasion

18

Malignancy that has a characteristic cannon ball appearance on CXR

Metastasis to the Lung

19

Preferential route of metastasis of carcinomas

Lymphatic

20

Preferential route of metastasis of sarcomas

Hematogenous

21

2 carcinomas that spread via hematogenous dissemination

Renal cell carcinoma and hepotocellular CA

22

Responsible for the cachexia and wasting in malignancy

TNF-a or cachectin

23

Cushing sundrome is a paraneoplastic syndrome of what malignancy

Small cell (oat cell) carcinoma of the lung


Production of ACTH-like substances

24

Inappropriate secretion of ADH is a paraneoplastic syndrome of what malignancy

Small cell carcinoma of the lung

25

Paraneoplastic syndrome characterized by sudden appearance of multiple seborrheic keratoses

Leser-Trelat sign

26

Converts B-naphthylamine glucuronide to the carcinogenic B-naphthylamine

Mucosal glucuronidase


Example of indirect-reacting carcinogens

27

Malignancy obtained from excess sun exposure

Squamous cell carcinoma and basal cell carcinoma of skin; melanoma


Due to induction of thymine dimers

28

Malignancy resulting from alkylating agents

Acute leukemia