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Flashcards in Neoplasia Deck (29)
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1

-oma usually connotes a benign tumor except

seminoma
lymphoma
melanoma
hepatoma

2

___ is a tumor-like condition where an ectopic tissue is cytologically and architecturally normal

Choristoma/Ectopia

3

____ is the first node in a regional lymphatic basin that receives lymph flow from the primary tumor

sentinel lymph node

4

Most common CA in children

ALL

5

Most common CA in males

prostate

6

most common CA in females

breast

7

Most common CA that cause mortality

lung CA

8

Type of growth factor receptor that is encoded by oncogenes

Tyrosine Kinase

9

[name the protooncogene]

Polycythemia vera, essential thrombocytosis, primary myelofibrosis

JAK 2

10

[name the protooncogene]

Hairy cell leukemia

BRAF

11

[name the protooncogene]

Burkitt lymphoma, Neuroblastoma

MYC

12

[name the protooncogene]

Glioblastoma
Melanoma

CDK4

13

[tumor suppressor gene]
G1-S phase cell cycle checkpoint

Normally, active when hypophosphorylated

Rb: becomes hyperphosphorylated --> inactivated

"governor of the cell"

14

[tumor suppressor gene]

this monitors the stress in the cell

activated by: anoxia, inappropriate signalling by mutated oncoproteins, DNA damage

p53:

"Guardian of the genome"

15

Liver fluke infection that cause cholangiocarcinoma

Chlonorchis sinensis
Opintorchis viverrini

16

HHV 5 =

CMV

17

HHV 4

EBV

HHV 1 = HSV

18

HHV 1 =
HHV 2 =
HHV 3
HHV 4
HHV 5
HHV 6
HHV 7
HHV 8

HHV 1 = HSV 1
HHV 2 = HSV 2
HHV 3 = VZV
HHV 4 = EBV
HHV 5 = CMV
HHV 6 = Roseola
HHV 7 = Roseola-like
HHV 8 = Kaposi

19

CA associated in exposure to PVC pipes

Liver Angiosarcoma

Vinyl chloride in PVC pipe

20

[paraneoplastic syndrome]

Cushing syndrome due to excessive ACTH or ACTH-like substances

Small cell lung CA
Pancreatic CA
Neural tumors

21

[paraneoplastic syndrome]

SIADH due to increased ADH or ANP

Small cell lung CA
Oat cell lung CA
Intracranial Lung CA

22

[paraneoplastic syndrome]

Hypercalcemia due to increased PTHrP, TGF alpha, TNF, IL-1

due to cancer-induced bone disease

Squamous cell CA
Breast CA
Renal Cell CA

23

aside from thymic neoplasms, myasthenia gravis is associated with what CA

bronchogenic carcinoma

24

[paraneoplastic syndrome]

This dermatologic manifestation is due to increased production of EGF. Associated with gastric CA, lung CA, uterine CA

acanthosis nigricans

25

[paraneoplastic syndrome]

Hypertrophic osteoarthritis
Clubbing of finger

bronchogenic CA
Thymic neoplasm

26

[paraneoplastic syndrome]
migratory thrombophlebitis due to tumor products that activate clotting

pancreatic CA
bronchogenic CA

27

In tumor grading ang staging,

this is more reflective of biologic behavior of cancer

cancer stage

28

Abnormalities in tumor lysis syndrome

hyperkalemia
hyperphosphatemia
hyperuricemia
hypocalcemia

29

The most common clinical consequence of tumor lysis syndrome.

urate nephropathy