Neoplasms Flashcards Preview

Neuro 2 Midterm > Neoplasms > Flashcards

Flashcards in Neoplasms Deck (97):
1

Temporal cortical lobe, BRAF

Ganglioglioma (childhood neuronal)

2

Condition associated w/ schwannoma

NF-2

3

Antoni A + B

Schwannoma

4

Merlin induced EGFR upregulation

Schwannoma

5

Verocay bodies

Schwannoma

6

Condition associated w/ neurofibroma

NF-1

7

KIT ligand and CD-34 Spindle cells

Neurofibroma

8

Pseudo-Meissner corpuscles (Tactile Like Bodies)

Diffuse Neurofibroma (plaques in skin, fat)

9

"Bag of worms" and "shredded carrot" morphology

Plexiform neurofibroma

10

Condition associated with MPNST

NF-1

11

Rhabdomyoblastic MPNST

Triton tumor

12

5 tumors of NF-1

CNS Hamartoma
Optic nerve glioma
MPNST
Pheochromocytoma
Neurofibroma

13

3 tumors of NF-2

Schwannoma
Meningioma
Spinal cord ependymoma
Glial hamartia (usually in cortex)

14

Ch 17

NF-1

15

Ch 22

NF-2

16

Rosenthal fibers

Pilocytic astrocytoma with Rosenthal fibers

17

Typical choroid plexus tumor

Hamartoma

18

Diffuse astrocytoma grade

2

19

Gemistocytic astrocytoma

Very reactive eosinophilic grade 3

20

PTEN, EGFR
CH 9, 10 (RB, P53)

Classic subtype glioblastoma

21

IDH1, 2, p53, over expressed PDGFRA

Proneural subtype, glioblastoma

22

NEFL, GABRA1, SYT1, SKC12A5

Neural subtype, glioblastoma

23

NF 1 deletion

Glioblastoma mesenchymal subtype

24

Young adult, midline brainstem, cystic, Rosenthal and granular

Pilocytic astrocytoma

25

BRAF

Pilocytic astrocytoma

26

Perineuronal satellitosis, halos, IDH

Oligodendroglioma

27

IDH = better prognosis in

Oligodendroglioma, glioblastoma

28

Reticulin deposits

Xanthoastrocytoma

29

Grade, prognosis, pt xanthoastrocytoma

2, decent, child

30

3 classes, brainstem glioma (well differentiated)

Intrinsic pontine - bad

Cervicomedullary junction - ok

Dorsally exophytic (tectal) - benign

31

Co deletion 1,19 oligodendroglioma

More susceptible to chemo

32

Posterior fossa ependymoma

Location ='worse prognosis

33

Lumen pseudorosettes

Ependymoma

34

Grade, ependymoma

2, 3

35

Subtypes, ependymoma

Mesenchemal -- younger, worse
Whole chromosome aberration - better

NO p53 MUTATIONS

36

Myxopapillary ependymoma

Filum terminale

37

Subependymoma

Calcified lesions in ventricle

38

Colloid ventricular cyst

3rd ventricle, foramen of monroe
Non-communicating
If headache, rapidly fatal

39

Choroid papilloma location, kid or adult

Kid - lat ventricle
Adult - 4

40

Young child w unexplained seizure, think

Neuronal tumor

41

Grade 1 myxoid in temporal lobe with skull attenuation

Dysembryoplastic neuroepithelial tumor (childhood neuronal)

42

Grade 2, neuropil islands, ventricles

Central neurocytoma (childhood neuronal)

43

Drop (distant) metastasis

Medulloblastoma

44

Crescent nuclei

Medulloblastoma

45

Ki67

Medulloblastoma

46

Homer Wright rosettes

Neuroblastoma or medulloblastoma

47

B catenin elevation

Wnt type medulloblastoma
Good prog
Older kids

48

MCYN amp alone

Medulloblastoma Shh
Middling prog
Infants, teens

49

MYC amp, i17q, large cell

Medulloblastoma group 3
WORST

50

MYCN, i17q
Middling prog

Group 4 medulloblastoma

51

Indicator of worst prognosis, medilloblastoma

i17q

52

CNS primitive ecto tumor (CNS PNET)

Medulloblastoma in cortex

53

Grade, atypical embryonal tumor

4

54

Gene hSNF5, INI1 on ch 22

Embryonal atypical rhabdoid teratoid tumor

55

Prognosis primary CNS lymphoma

Very bad

56

CD20, EBER snRNA, "hooping" pattern around vessels

Primary CNS lymphoma

57

Neoplastic cause of widespread microinfarcts and dementia

Intravascular lymphoma

58

Germinoma

Pineal/suprasellar

59

Pinealcytoma vs pinealblastoma

Cytoma - good, kids
Blastoma - bad, adults

60

Located at bone landmarks

Meningioma

61

Derived from arachnoid meningeal cells with dural attachment

Meningioma

62

Has progesterone receptors

Meningioma

63

Psamomma bodies

Meningioma

64

Encapsulated or en plaque

Meningioma

65

Whorl shaped syncytial cells with fibroblasts and keratin from secretory cells

Meningioma

66

Carcinoembryonic Ag

Meningioma

67

Osseous metaplasia

Meningioma

68

TRAF7 (TNF receptor)

Benign meningioma
More secretory cells = more treatable

69

Prognosis, meningioma typical w NF2

worse than usual

70

Subtypes, anaplastic meningioma

Papillary - pleomorphic w fibrovascular core
Rhabdoid - sheets of filament w hyaline core

71

Epithelial membrane Ag

Meningioma, all types

72

Choriocarcinoma (uterus)

Always to brain

73

Meningeal carcinomatosis

Lung, breast cancer

74

Lung cancer ANNA to this lobe

Temporal

75

Subacute cerebellar degeneration (PC1 Ab's)

Ovarian, uterine, breast

76

LiFraumeni

Medulloblastoma

77

TSC1, 2

1- hamartin
2- tuberin

78

Shagreen and Ash leaf patches
Retardation, autism, seizures

Tuberous sclerosis

79

Subependymal giant cell astrocytoma with massive cells

Unique to tuberous sclerosis

80

Inhibin

VHL

81

MGMT

Better outcome for astrocytom

82

Mtor

Tuberous sclerosis, cells get too big

83

Mtor

Tuberous sclerosis, cells get too big

84

Eyelid lipogranuloma

Chalazion

85

Subacute cerebellar degeneration

PCA1
Ovary
Uterus
Breast

86

Limic encephalitis dementia

Lung anna1
Ovary NMDA (hippocampus)

87

Cerebellar or retinal hemangioblastoma

Von hippel lindau

88

MDM2

Glioblastoma

89

Pink, plump cells

Meningioma

90

Polycythemia

Hemangioblastoma

91

Pink, plump cells

Meningioma

92

Polycythemia

Hemangioblastoma

93

Hemangioma, renal cell carcinoma, pheochromocytoma

VHL AD

94

Hamartomas of all sorts, cardiac rhabdo, renal lipoma

Tuberous sclerosis AD

95

Hemangioma, renal cell carcinoma, pheochromocytoma

VHL AD

96

Hamartomas of all sorts, cardiac rhabdo, renal lipoma

Tuberous sclerosis AD

97

Chromosome 13

Retinoblastoma