Nephritic Syndrome

Question 1

Features of Nephritic syndrome ?

Answer 1

1. Glomerular inflammation ‘
2. Bleeding
3. Proteinuria <3.5g/day
4. Salt retention
5. OLiguria
6. Azotemia
7. Urine-RBC cast & Dysmorphic RBC
8. HTN
9. Periorbital edema

Question 2

Biopsy of nephritic syndrome ?

Answer 2

1. Hypercellular
2. Inflammed glomeruli

Question 3

Damage process in nephritic syndrome ?

Answer 3

Immune co plex mediated activation of complex C5a - that attacts neutrophils - Damage

Pathoma-130

Question 3

PSGN features ?

Answer 3

1. Hematuria-Coca cola urine
2. Oliguria
3. HTN
4. Periorbital edema

Question 3

Post streptococcal glomerulonephritis
PSGN ?

Answer 3

Group-A Beta hemolytic streptococcal infection

Question 4

PSGN site ?

Answer 4

1. Skin - Impetigo
2. Pharynx

Question 5

IF result in PSGN ?

Answer 5

+
Subepithelial HUMP on EM

Question 5

Tx of PSGN ?

Answer 5

Supportive

Question 6

H & E result in PSGN ?

Answer 6

Hypercellular
Inflammed glomeruli

Question 7

Progresion of PSGN ?

Answer 7

1. Adult = Rapidly Progressive Glomerulonephritis
2. Child = renal F

Question 8

Rapidly Progressive Glomerulonephritis ?

Answer 8

It progress to Renal F in weeks to months

Question 9

H & E stain in RPGN ?

Answer 9

Crescents in bowman space of glomeruli

Crescent= Fibrin + Macrophage

Question 10

IF = Granular ?

Answer 10

PSGN /
Diffuse Proliferative Glomerulonephritis

Question 11

IF = Linear ?

Answer 11

Goodposture syndrome

Question 12

Negative = IF - Pauci Immune

Answer 12

1. Wegener granulomatosis
2. Microscopic polyangitis
3. Churg-Strauss syndrome

Question 13

c-ANCA association ?

Answer 13

1. Wegener granulomatosis

Question 14

p-ANCA association ?

Answer 14

2. Microscopic polyangitis
3. Churg-Strauss syndrome

130

Question 15

PSGN / diffuse ProL GN which disease ?

Answer 15

SLE

Question 16

Goodposture syndrome manifestation ?

Answer 16

1. Anti basement membrane AB
2. Hematuria
3. Hemoptysis

Question 16

IgA nephropathy Other name ?

Answer 16

Berger disease

Question 17

IF result in BERGER D ?

Answer 17

IgA immune complex deposition in mesangium

pathoma-131

Question 17

IgA nephropathy manifestation ?

Answer 17

1. inc IgA production
2. Urine - RBC cast
3. Gastroenteritis
4. Hematuria

Question 18

Alport syndrome cause ?

Answer 18

Inherited defect in Type-4 collagen

X-linked

Question 18

AS features >

Answer 18

1. Hematuria
2. Sensory hearing loss
3. Ocular disturbance

Question 19

Churg strauss VS Microscopic polyangitis ? | as both p-ANCA

Answer 19

1. Asthma 2. Eosinophilia 3. Granulomatous inflammation | 130

Question 20

Progression of IgA nephropathy >?

Answer 20

Renal F