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Human Biology ATAR > NEUR3310 > Flashcards

NEUR3310 Flashcards

NEUR3310

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1
Q

central nervous system overview

A

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2
Q

neuron to neuron communication

A

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3
Q

neuropharmocology

A

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4
Q

drug targets

A

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5
Q

receptors

A

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6
Q

ion channels

A

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7
Q

enzymes

A

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8
Q

transporters

A

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9
Q

ion channels and receptor expression

A

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10
Q

the synapse

A

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11
Q

tripartite synapse

A

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12
Q

quadripartite synapse

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13
Q

electrical synapses

and mixed synapse

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14
Q

volume and pure spill transmission

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15
Q

neurotransmitters

A

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16
Q

definition of neurotransmitter

A

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17
Q

small molecule neurotransmitters

A

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18
Q

glutamate

A

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19
Q

glutamate receptors

A

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20
Q

ionotropic glutamate receptors

A

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21
Q

AMPA receptors

A

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22
Q

NMDA receptors

A

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23
Q

NMDA + AMPA receptors

A

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24
Q

NMDA receptors
glycine

A

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25
Q

ionotropic glutamate receptors 2

A

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26
Q

metabotropic glutamate receptors

A

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27
Q

metabotropic glutamate receptors 2

A

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28
Q

GluR in the nervous system

long term potentiation, long term depression

A

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29
Q

GABA

and also synthesis and removal

A

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30
Q

GABA receptors

A

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31
Q

GABA A receptors

A

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32
Q

GABA B receptors

A

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33
Q

neuromodulators

A

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34
Q

adenosine

A

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35
Q

Acetylcholine

A

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36
Q

ACh receptors in the brain

A

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37
Q

neuropeptides

A

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38
Q

neuropeptide receptors

A

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39
Q

presynaptic modulation with neuropeptides

A

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40
Q

nitric oxide (NO)

A

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41
Q

chemokines

A

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42
Q

Cre-lox origins

A

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43
Q

cre lox: gene knockout

A

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44
Q

cre lox: gene expression

A

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45
Q

cre lox inversion

A

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46
Q

DIO and DO systems

A

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47
Q

DIO cre on

A

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48
Q

DO cre off

A

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49
Q

how does cre get into cells

A

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50
Q

Promoters

A

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51
Q

Cre lox viruses

A

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52
Q

transgenic cre lines

A

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53
Q

CreERT activating Cre at a specific time

A

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54
Q

temporal control over Cre recombination

A

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55
Q

neuroscience applications
cell labelling

A

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56
Q

neuroscience applications
gene knock out

A

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57
Q

neuroscience applications
gene knock in

A

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58
Q

caveats of cre lox

A

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59
Q

controlling neural activity

A

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60
Q

chemogenetics

A

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61
Q

DREADDs

A

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62
Q

hM3Dq

A

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63
Q

hM4Di

A

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64
Q

silencing synapses with hM4Di

A

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65
Q

Axon selective hM4Di

A

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66
Q

K opioid derived DREADD

A

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67
Q

CNO

A

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68
Q

CNO alternatives

A

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69
Q

Salvorin B

A

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70
Q

DREADDs to interrogate behaviour

A

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71
Q

DREADDs in drug development

A

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72
Q

Synthetic ion channel: GluCl

A

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73
Q

synthetic ion channel: glycinergic channel

A

lecture 6

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74
Q

neuron overview

A

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75
Q

non invasive brain stimulation

A

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76
Q

invasive brain stimulation

A

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77
Q

brain stimulation

A

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78
Q

optogenetics

A

lecture 7

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79
Q

phototransduction

A

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80
Q

opsins

A

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81
Q

channelrhodopsin

A

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82
Q

optogenetics

A

lecture 7

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83
Q

opsin variants: neuronal silencing

A

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84
Q

opsin variants

A

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85
Q

in vivo optogenetics

A

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86
Q

in vivo optogenetics
optrodes
fibre implants

A

lecture 7

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87
Q

applications behaviour

A

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88
Q

applications addiction

A

lecture 8

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89
Q

application memory

A

lecture 8

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90
Q

applications neurogenesis

A

lecture 8

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91
Q

applications therapeutics

A

lecture 8

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92
Q

optogenetics in humans

A

lecture 8

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93
Q

patch clamp electrophysiology

A

lecture 9

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94
Q

current clamp patch clamp electrophysiology

A

lecture 9

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95
Q

voltage clamp patch clamp electrophysiology

A

lecture 9

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96
Q

brain slice patch clamp electrophysiology

A

lecture 9

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97
Q

in vivo patch clamp electrophysiology

A

lecture 9

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98
Q

patch clamp electrophysiology

A

lecture 9

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99
Q

toxins

A

lecture 9

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100
Q

toxins and sodium voltage channels

A

lecture 9

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101
Q

toxins and potassium voltage channels

A

lecture 9

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102
Q

toxins and glutamate receptors

A

lecture 9

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103
Q

bacterial toxins

A

lecture 9

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104
Q

microscopy to study neural activity

A

lecture 10

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105
Q

fluorescence

A

lecture 10

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106
Q

calcium imaging

A

lecture 10

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107
Q

genetically coded calcium indicators

A

lecture 10

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108
Q

calcium imaging applications in neuroscience

A

lecture 10

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109
Q

calcium imaging limitations

A

lecture 10

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110
Q

voltage imaging

A

lecture 10

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111
Q

imaging neurotransmitters

A

lecture 10

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112
Q

dopamine sensors

A

lecture 10

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113
Q

sodium imaging

A

lecture 10

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114
Q

psychosis symptoms

A

lecture 11

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115
Q

antipsychotics

A

lecture 11

116
Q

dopamine receptors

A

lecture 11

117
Q

dopamine neurons

A

lecture 11

118
Q

schizophrenia/psychosis physiology

A

lecture 11

119
Q

dopamine terminal

A

lecture 11

120
Q

amphetamines

A

lecture 11

121
Q

amphetamine psychosis

A

lecture 11

122
Q

dopamines role

A

lecture 11

123
Q

dopamine and predictions errors

A

lecture 11

124
Q

dopamine maths

A

lecture 11

125
Q

dopamine and reward learning

A

lecture 11

126
Q

incentive salience

A

lecture 11

127
Q

dopamine, incentives and psychosis

A

lecture 11

128
Q

delusions vs hallucinations

A

lecture 11

129
Q

addiction substance use disorders

A

lecture 12

130
Q

stages of addiction

A

lecture 12

131
Q

binge/intoxication

A

lecture 12

132
Q

chronic drug use

A

lecture 12

133
Q

habit formation

A

lecture 12

134
Q

chronic drug use: withdrawal/ negative affect

neuroadaptation

A

lecture 12

135
Q

preoccupation/anticipation

A

lecture 12

136
Q

craving

A

lecture 12

137
Q

feedback loop

A

lecture 12

138
Q

breaking out of the loop

A

lecture 12

139
Q

pharmacological methods

A

lecture 12

140
Q

replacement with safer option

A

lecture 12

141
Q

methadone

A

lecture 12

142
Q

reduce craving and withdrawal symptoms

A

lecture 12

143
Q

increase negative effects

A

lecture 12

144
Q

new targets and methods

A

lecture 12

145
Q

tinnitus

A

lecture 13

146
Q

peripheral auditory pathway

A

lecture 13

147
Q

peripheral sense organ
cochlea

A

lecture 13

148
Q

central auditory pathway

A

lecture 13

149
Q

cochlea

A

lecture 13

150
Q

cochlear trauma

A

lecture 13

151
Q

hearing loss

A

lecture 13

152
Q

hearing loss and tinnitus

A

lecture 13

153
Q

peripheral deafferentation

A

lecture 13

154
Q

central auditory response

A

lecture 13

155
Q

neural hyperactivity

A

lecture 13

156
Q

neural hyper excitability

A

lecture 13

157
Q

approaches for investigating tinnitus

A

lecture 13

158
Q

hair cell ion channel

A

lecture 13

159
Q

targeting central hyperexcitabilty

A

lecture 13

160
Q

animal model of tinnitus

A

lecture 13

161
Q

neural substrate of tinnitus

A

lecture 13

162
Q

dysfunctional gating theory of tinnitus

A

lecture 13

163
Q

targeting hyperactivity

A

lecture 13

164
Q

inhibitory transmission

A

lecture 13

165
Q

GABA in an animal model

A

lecture 13

166
Q

cancer and cancer neuroscience

A

lecture 14

167
Q

hallmarks of cancer

A

lecture 14

168
Q

treatment and disadvantages

A

lecture 14

169
Q

ion channels

A

lecture 14

170
Q

chemical synapses

A

lecture 14

171
Q

how do drugs act on ion channels

A

lecture 14

172
Q

electro physiology patch clamp

A

lecture 14

173
Q

why are ion channels a good target to treat brain cancer

A

lecture 14

174
Q

ion channels are essential for…

A

lecture 14

175
Q

ion channels difficult drug targets

A

lecture 14

176
Q

brain tumours

A

lecture 14

177
Q

glioblastoma

A

lecture 14

178
Q

mutations in glioblastoma

A

lecture 14

179
Q

current treatment of GBM

A

lecture 14

180
Q

Xenograft mouse models

A

lecture 14

181
Q

Brain cancer is electrically active

A

lecture 14

182
Q

glutamatergic neuron
glioma synapse

A

lecture 14

183
Q

optogenetics and GBM

A

lecture 14

184
Q

possible targets for ion channel drugs

A

lecture 14

185
Q

causes and symptoms of depression

A

lecture 15

186
Q

monoamine hypothesis

A

lecture 15

187
Q

transporters and enzymes of monoamines

A

lecture 15

188
Q

monoaminergic hypothesis

A

lecture 15

189
Q

monoamine inhibitors

A

lecture 15

190
Q

monoamine transporters as a target

A

lecture 15

191
Q

SSRIs

A

lecture 15

192
Q

SMS

serotonin receptors

A

lecture 15

193
Q

tricyclic antidepressants

A

lecture 15

194
Q

atypical drugs

A

lecture 15

195
Q

glutamate involvement in depression

A

lecture 15

196
Q

glutamatergic drug targets

A

lecture 15

197
Q

ketamine

A

lecture 15

198
Q

other drugs targeting NMDA receptor

A

lecture 15

199
Q

riluzole

A

lecture 15

200
Q

inflammation and infection

A

lecture 15

201
Q

anxiety disorder

A

lecture 16

202
Q

neurobiology of anxiety

A

lecture 16

203
Q

hypothalamus and anxiety

A

lecture 16

204
Q

sedatives and anxiolytics

A

lecture 16

205
Q

GABA

A

lecture 16

206
Q

benzodiazepines

A

lecture 16

207
Q

benzodiazepines and GABA a receptors

A

lecture 16

208
Q

benzodiazepines and anxiety

A

lecture 16

209
Q

benzodiazepines and dependence

A

lecture 16

210
Q

barbiturates

A

lecture 16

211
Q

anti-epileptic/anti-convulsants

A

lecture 16

212
Q

serotonin 5-HT

A

lecture 16

213
Q

5-HT receptors

A

lecture 16

214
Q

azapirones

A

lecture 16

215
Q

SSRIs

A

lecture 16

216
Q

xenon gas

A

lecture 16

217
Q

kava

A

lecture 16

218
Q

dementia

A

lecture 17

219
Q

dementia pathophysiology

A

lecture 17

220
Q

macroscopic brain changes

A

lecture 17

221
Q

amyloid-B toxicity

A

lecture 17

222
Q

Tau

A

lecture 17

223
Q

amyloid beta and tau interactions

A

lecture 17

224
Q

amyloid hypothesis controversy

A

lecture 17

225
Q

apolipoprotein E

A

lecture 17

226
Q

AChE inhibitors

A

lecture 17

227
Q

donepezil

A

lecture 17

228
Q

rivastigime

A

lecture 17

229
Q

memetine

A

lecture 17

230
Q

amyloid b antibodies

A

lecture 17

231
Q

scanning ultrasound stimulation

A

lecture 17

232
Q

Parkinsons disease

A

lecture 18

233
Q

lewy bodies

A

lecture 18

234
Q

pathogenesis

A

lecture 18

235
Q

protein misfolding and aggregations

A

lecture 18

236
Q

oxidative stress

A

lecture 18

237
Q

alpha synuclein

A

lecture 18

238
Q

animal models of PD

A

lecture 18

239
Q

6-OHDA
behaviour

A

lecture 18

240
Q

stereotaxic surgery

A

lecture 18

241
Q

L-DOPA

A

lecture 18

242
Q

Amantadine
dopaminergic system
glutamatergic system

A

lecture 18

243
Q

monoaminoxidase inhibitors

A

lecture 18

244
Q

a-synuclein targeted therapies

A

lecture 18

245
Q

deep brain stimulation

A

lecture 18

246
Q

types of stroke

A

lecture 19

247
Q

post stroke phases

A

lecture 19

248
Q

excitotoxicity in stroke

A

lecture 19

249
Q

NMDAR subtypes

A

lecture 19

250
Q

NMDAR overstimulation

A

lecture 19

251
Q

role of astrocytes

A

lecture 19

252
Q

post stoke changes to GABA function

A

lecture 19

253
Q

intravenous thrombolytic therapy

A

lecture 19

254
Q

secondary degeneration

A

lecture 19

255
Q

antioxidants

A

lecture 19

256
Q

visual system and retina

A

lecture 20

257
Q

glaucoma overview

A

lecture 20

258
Q

mechanisms of glaucoma

A

lecture 20

259
Q

diagnosis of glaucoma

A

lecture 20

260
Q

surgical interventions

A

lecture 20

261
Q

pharmacological interventions

A

lecture 20

262
Q

cholinergic agents

A

lecture 20

263
Q

prostaglandin analogs

A

lecture 20

264
Q

BDNF

A

lecture 20

265
Q

Stem cell therapy

A

lecture 20

266
Q

endocannabinoid system

A

lecture 21

267
Q

neurotransmitters vs endocannabinoids

A

lecture 21

268
Q

endocannabinoids

A

lecture 21

269
Q

eCB synthesis

A

lecture 21

270
Q

eCB transport

A

lecture 21

271
Q

CB1 receptor

A

lecture 21

272
Q

CB2 receptor

A

lecture 21

273
Q

depolarisation induced suppression

A

lecture 21

274
Q

glia involvement

A

lecture 21

275
Q

neuromodulation of serotonin and dopamine

A

lecture 21

276
Q

phytocannabinoids

A

lecture 21

277
Q

THC

A

lecture 21

278
Q

CBD

A

lecture 21

279
Q

drugs that target ECS

A

lecture 21

280
Q

reciprocal action onto ECS

A

lecture 21

281
Q

Psychosis

A

lecture 22 cannabinoids

282
Q

Parkinsons

A

lecture 22 cannabinoids

283
Q

alzheimers

A

lecture 22 cannabinoids

284
Q

glaucoma and retinal degenerative disorders

A

lecture 22 cannabinoids

285
Q

stroke

A

lecture 22 cannabinoids

286
Q

glioblastoma

A

lecture 22 cannabinoids

287
Q

mood disorders

A

lecture 22 cannabinoids

Human Biology ATAR (24 decks)

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