Flashcards in Neuro Modulators Deck (102)
What are the Amphetamine-based stimulants?
What are the indications for amphetamine?
How does amphetamine treat narcolepsy?
Keeps the CNS running at a high rate of activity
What is the MOA of amphetamine?
Stimulates CNS via a sympathomimetic mechanism involved the enhanced release and reduced reuptake of norepinephrine and dopamine
What are the common side effects of amphetamine?
What are the serious side effects of amphetamine?
Amphetamines increase the release of what at the synaptic cleft?
Why are photosensitivity and visual disturbance common with amphetamine use?
Can cause mydriasis
What is the effect produced by the interaction of CAIs and amphetamine?
Renal excretion decreased in alkaline urine
What is the effect produced by the interaction of sympathomimetics and amphetamine?
What is the effect produced by the interaction of ophthalmic beta-blockers and amphetamine?
What is the effect produced by the interaction of NSAIDs and amphetamine?
Caffeine-based additive effects
When would be a situation in which it might be common to see an issue with amphetamine and sympathomimetic interactions?
A narcoleptic being treated for glaucoma (glaucoma drugs are often sympathomimetics
When is amphetamine contraindicated?
What is the biogenic amine theory for antidepressants?
There is a deficiency in monoamines (norepinephrine and serotonin)
SSRIs are designed not to influence which monoamine?
Which monoamine is acted on my SNRIs?
Both norepinephrine and serotonin
What kind of antidepressant is imiparmine?
What is MAO responsible for?
Biogenic amine degradation
What are the 6 SSRI antidepressants?
Which SSRI is the "s" enantiomer of citalopram?
The majority of SSRI antidepressants end in what suffix?
What is the indication for Excitalopram (SSRI)?
Major depressive disorder
Generalized anxiety disorder
What is the MOA of escitalopram?
What are the common side effects of escitalopram?
What are the distinguishing side effects of escitalopram?
Neuroleptic malignant syndrome
What is neuroleptic malignant syndrome?
High levels of serotonin in the body - life threatening
Why might escitalopram cause dry eye?
Fight and flight turns off all the body's glands, except the sweat glands, causing a lack of tear production
What are the effects of an interaction between NSAIDs and Escitalopram? (Omega-3s as well)