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Flashcards in Neuro Modulators Deck (102)
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1

What are the Amphetamine-based stimulants?

Amphetamine
Dextroamphetamine
Methylphenidate

2

What are the indications for amphetamine?

ADHD
Narcolepsy

3

How does amphetamine treat narcolepsy?

Keeps the CNS running at a high rate of activity

4

What is the MOA of amphetamine?

Stimulates CNS via a sympathomimetic mechanism involved the enhanced release and reduced reuptake of norepinephrine and dopamine

5

What are the common side effects of amphetamine?

Photosensitivity
Visual disturbance
Elevated BP
Infection
Headache

6

What are the serious side effects of amphetamine?

Dependency
Abuse
Psychosis
Growth suppression
Heart failure
Steven's-Johnson syndrome

7

Amphetamines increase the release of what at the synaptic cleft?

Biogenic amines

8

Why are photosensitivity and visual disturbance common with amphetamine use?

Can cause mydriasis

9

What is the effect produced by the interaction of CAIs and amphetamine?

Renal excretion decreased in alkaline urine

10

What is the effect produced by the interaction of sympathomimetics and amphetamine?

Hypertensive crisis
Arrhythmia

11

What is the effect produced by the interaction of ophthalmic beta-blockers and amphetamine?

Hypertensive crisis

12

What is the effect produced by the interaction of NSAIDs and amphetamine?

Caffeine-based additive effects

13

When would be a situation in which it might be common to see an issue with amphetamine and sympathomimetic interactions?

A narcoleptic being treated for glaucoma (glaucoma drugs are often sympathomimetics

14

When is amphetamine contraindicated?

With glaucoma

15

What is the biogenic amine theory for antidepressants?

There is a deficiency in monoamines (norepinephrine and serotonin)

16

SSRIs are designed not to influence which monoamine?

Norepinephrine

17

Which monoamine is acted on my SNRIs?

Both norepinephrine and serotonin

18

What kind of antidepressant is imiparmine?

TCAD

19

What is MAO responsible for?

Biogenic amine degradation

20

What are the 6 SSRI antidepressants?

Escitalopram
Sertaline
Fluoxetine
Paroxetine
Fluvoxamine
Citalopram

21

Which SSRI is the "s" enantiomer of citalopram?

Escitalopram

22

The majority of SSRI antidepressants end in what suffix?

-ine

23

What is the indication for Excitalopram (SSRI)?

Major depressive disorder
Generalized anxiety disorder

24

What is the MOA of escitalopram?

SSRI

25

What are the common side effects of escitalopram?

Dizziness

26

What are the distinguishing side effects of escitalopram?

Suicidal risk
Serotonin syndrome
Neuroleptic malignant syndrome
Siezures

27

What is neuroleptic malignant syndrome?

High levels of serotonin in the body - life threatening

28

Why might escitalopram cause dry eye?

Fight and flight turns off all the body's glands, except the sweat glands, causing a lack of tear production

29

What are the effects of an interaction between NSAIDs and Escitalopram? (Omega-3s as well)

Hemorrhage risk

30

What are the effects of an interaction between ophthalmic beta blockers and escitalopram?

Reduced beta-blocker metabolism