neurodegenerative and neuromuscular drugs Flashcards Preview

Nursing N369 Pharmacology II > neurodegenerative and neuromuscular drugs > Flashcards

Flashcards in neurodegenerative and neuromuscular drugs Deck (26):
1

Astrocytes

help move impulses across the synaptic cleft

2

Multiple Sclerosis

disease of destruction and demyelization
multifactorial disease
MS tends to be more common in female
specific viral infections increase chances - epstein barr virus - can be second to influenza shot
vitamin D deficiency or excess/over exposure to UV

3

one of first signs of MS

optic neuritis - may have pain when moving eyes up and down; double vision - weakening of muscles around optic cavity

4

Overwhelming complaint of fatigue
painful muscle spasms or loss of strength
touch, pain and temperature sensations

these are signs of what?

multiple sclerosis

5

Disease modifying agents
immunosuppressants
monoclonal antibody therapy

all these are examples of treatment modalities for?

MS, Disease modifying agents and immunosuppressants just enhance the quality of life

6

Disease modifying agents (MDA)

They don't cure but rather alter the experience of disease

*INTERFERON B, 1B, 1A are ALL DISEASE MODIFYING AGENTS (don't need to know specifics of what does what)

7

give examples of interferons

help mediate and mask the inflammatory response

Betaseron
Glatiramer acetate (Copaxone)
Avonex
Rebif


8

monoclonal antibiotic

Natalizumab (Tysabri) - CAUSE GLUCOENCAPHALOPATHY - liver begins to digest WBC and RBC and get anoxia, so liver can't detoxify other agents

will cause exacerbation before you get relief.

9

Novantrone

immunosuppressant - can cause PT skin to have BLUE/GREEN TINT; skin, urin, and sclera turn almost cyanotic blue.

SEs:
hair loss, N/V, menstrual irregularities

10

Symmetrel

can help regulate or delay impulse transmission in MS, but most often used with patients that have in myasthenia gravis

11

progressive weakeness and lack of muscle control with periodic acute episodes define what condition

myasthenia gravis - SLE may dispose individual to getting this

12

this have direct relation to destruction of Ach receptors

myasthenia gravis

13

acetylcholinesterase

enzyme that breaks down Ach

14

acetylcholinesterase inhibitors can be used to treat?

myasthenia gravis - such as neostigmine

15

loss of Ach neuron as well as decline in Ach neurons marks what disease?

Alzheimer's

16

tacrine was the first drug to treat?

Alzheimer's

17

rivastimine

help assis in swallowing by allowing rece

18

donepezil

ONCE A DAY DOSING
for alzheimer's

19

indirect-acting cholinergic agonists

used to treat alzheimer's and by blocking acetylcholinesterase than can help Ach because nothing there to break down

Contraindications: allergies, bradycardia, GI obstructions, lactation

Caution - any condition that could help exacerbate cholinergic stimulation
asthma, coronary disease, peptic ulcers

20

adverse reactions of anticholingergics

bradycardia, hypotension, run to NSAIDS

21

Parkinson's Disease is characterized by

death of neurons that produce the NT dopamine in CNS including nigastrial pathway (EPS)

22

degeneration of neuron in nigrostrial pathway affects imbalance of the neurotransmitters ___________ (inhibitory) and ________(stimulatory), resulting in the difficulty in controlling posture, muscle tone, and involuntary muscle movement

dopamine and Ach

23

dopamine is a _______ NT

inhibitory

24

Ach is a _______ NT

Excitatory

25

dopamine is responsible for

mood, sleep and cognition; so parkinson's patients start off cognitively okay but in later stages may have mental decline

26

pill rolling, muscle rigidity, shuffling gait mark what disease?

Parkinson's