Neurodegenerative Disorders

Question 1

Define Neurodegenerative disease?

Answer 1

Progressive Neuronal loss, usually of late onset and unknown aetilogy

Question 2

What do we call clearly inherited neurodegenerative disorders?

Answer 2

Mendelian Genetic Cases

These often have a younger onset

Question 3

What are the two major Neurodegenerative disorders?

Answer 3

Dementia

Parkinson’s disease

Question 4

Define Dementia

Answer 4

Progressive impairment of multiple domains of cognitive function leading to loss of acquired skills and interference in occupational and social roles

Question 5

Define Parkinson’s

Answer 5

A clinical syndrome of bradykinesia + atleast one of:

• Rigidity
• Tremors
• Postural Instability

Caused by progressive loss of dopaminergic neurons in the Substantia Nigra