Neurological Disorders - Multiple Sclerosis Flashcards Preview

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Flashcards in Neurological Disorders - Multiple Sclerosis Deck (14):
1

What is targeted in the CNS in multiple sclerosis?

Myelin sheaths

2

What is the etiology of multiple sclerosis?

Unclear - autoimmunity
Complex trait
Familial tendency (15x inc)
Viral trigger? - autoimmunity

3

What is the patho of multiple sclerosis?

Antibodies target myelin which leads to sclerotic patches (plaques) leading to inflammation and damage
Some oligodendrocytes are destroyed if the demyelination occurs in an area with oligodendrocytes

4

____ problems occur as a result of demyelination

Conduction

5

What varies based on where sclerosis occurs and location of targeting in multiple sclerosis?

Symptoms

6

Where are the most common areas of demyelination?

Optic nerve
Peri ventricular region
Cerebellum
Spinal cord
Brain stem

7

What infiltrate into plaques in MS? What about in acute inflm?

T lymphocytes and macrophages, in acute inflm neutrophils infiltrate too

8

Which neurons are affected in MS?

Motor and sensory neurons

9

What are manifestations of MS?

Visual impairment
Parasthesias (abnormal sensation - tingling)
Fatigue
Bowel and bladder dysfunction
Decreased muscle strength
Gait and coordination problems

10

How is MS diagnosed?

History and clinical presentation
MRI to image plaques
Analyze CSF for proteins (specifically antibodies)

11

What are the three reasons why proteins may appear in the CSF?

Damage to the BBB
Autoimmunity
Inflammation

12

What is the treatment for ms?

Steroids to diminish exacerbation for acute relapses
Methotrexate (must give folate with medication as it is an antifolate)
Interferon ( for patient with persisten relapses)
Symptomatic treatment

13

What does chronic exacerbation and remission entail in ms?

A individual goes into remission and then the mnft come back worsened

14

Who does multiple sclerosis most commonly affect?

Young women 20-40 because of autoimmunity