Flashcards in Neurological Disorders - Multiple Sclerosis Deck (14):
What is targeted in the CNS in multiple sclerosis?
What is the etiology of multiple sclerosis?
Unclear - autoimmunity
Familial tendency (15x inc)
Viral trigger? - autoimmunity
What is the patho of multiple sclerosis?
Antibodies target myelin which leads to sclerotic patches (plaques) leading to inflammation and damage
Some oligodendrocytes are destroyed if the demyelination occurs in an area with oligodendrocytes
____ problems occur as a result of demyelination
What varies based on where sclerosis occurs and location of targeting in multiple sclerosis?
Where are the most common areas of demyelination?
Peri ventricular region
What infiltrate into plaques in MS? What about in acute inflm?
T lymphocytes and macrophages, in acute inflm neutrophils infiltrate too
Which neurons are affected in MS?
Motor and sensory neurons
What are manifestations of MS?
Parasthesias (abnormal sensation - tingling)
Bowel and bladder dysfunction
Decreased muscle strength
Gait and coordination problems
How is MS diagnosed?
History and clinical presentation
MRI to image plaques
Analyze CSF for proteins (specifically antibodies)
What are the three reasons why proteins may appear in the CSF?
Damage to the BBB
What is the treatment for ms?
Steroids to diminish exacerbation for acute relapses
Methotrexate (must give folate with medication as it is an antifolate)
Interferon ( for patient with persisten relapses)
What does chronic exacerbation and remission entail in ms?
A individual goes into remission and then the mnft come back worsened