Neuromuscular and Movement disorder Drugs Flashcards Preview

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Flashcards in Neuromuscular and Movement disorder Drugs Deck (25):
1

Class of drugs used for muscle paralysis in surgery or mechanical ventilation?

Neuromuscular blocking drugs

2

MoA of Drug that causes depolarizing blockade?

Succinylcholine. Strong ACh agonist
Phase I: prolonged depol
Phase II: repolarized but blocked (receptors desensitized)

3

AChE inhibitors - effect on Phase I and II?

Phase I: potentiates block
Phase II: reverses block

4

Complications of depolarizing blockade?

HyperCa, HyperK, malignant hyperthermia

5

Non-depolarizing blockade - drug suffixes (exception), and MoA

-curonium (and tubcurarine); compete with ACh for receptors

6

Reverse non-depolarizing blockade with?

Neostigmine, edrophonium (AChE inhibitors)

7

MoA of drug used in malignant hyperthermia and neurleptic malignant syndrome?

Dantrolene. Prevents release of Ca from sarcoplasmic reticulum of skeletal muscle.

8

Drugs that can trigger malignant hyperthermia?

inhalation anesthetics (except N2O) and succinylcholine

9

PD drugs - DA agonists?

Ergot - Bromocriptine
non-ergot - pramipexole, ropinirole

10

PD drugs - Other use for drug that increases DA?

Amantadine. Antiviral against influenza A and rubella.

11

PD drugs - converted to DA?

L-Dopa

12

PD drugs - MoA of drug that prevents DA breakdown centrally?

Selegiline. MAO-B inhibitor
Entacapone, tolcapone (COMT inhibitors - prevent dopa degradation)

13

PD drugs - Class of drug that curbs excess ACh?

Benztropine. Antimuscarinics.
(PARK the BENZ)

14

For essential tremors, use?

B-Blocker. Propanolol

15

Full DA treatment?

BALSA
Bromocriptine
Amatadine
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
Antimuscarinics

16

MoA of drug given with L-dopa?

carbidopa - peripheral decarboxylase inhibitor. Prevents conversion of L-dopa to carbidopa in periphery

17

Long term use can lead to dyskinesia with doses and akinesia between doses?

L-Dopa

18

increased peripheral DA can lead to?

arrhythmias

19

MoA of drug that may enhance the adverse effects of L-dopa?

Selegiline (inhibits MAO-B)

20

ALZ pt comes in with dizziness, confusion, hallucinations. Mech of Drug with these side effects?

Memantine. NMDA antag - precents Ca excitotoxicity

21

ALZ pit takes drug can won't go to sleep. Also has nausea and dizzines. MoA of drugs?

Donepezil, galantamine, rivastigmine. AChE inhibitors.

22

Pt with decreased GABA, decreased ACh and increased DA. Goal of treatment? Drugs

Huntington's - decrease DA.
Tetrabenazine and reserpine - inhibit VMAT (decrease DA packaging)
Haloperidol (DA receptor antag)

23

MoA for Drug for acute migraine.

Sumatriptan. 5HT1b/1d agonist.
1)Inhibits trigeminal nerve activation
2) prevents vasoactive peptide release
3) induces vasoconstriction

24

Pt with chronic episodes of pain comes in with coronary vasospasm and tingling. Drug that could have caused it?

Sumatriptan

24

MoA of drugs that decrease L-DOPA degradation peripherally?

Entacapone, tolcapone (COMT inhibitors - prevent dopa degradation)