Flashcards in Neuromuscular and Movement disorder Drugs Deck (25):
Class of drugs used for muscle paralysis in surgery or mechanical ventilation?
Neuromuscular blocking drugs
MoA of Drug that causes depolarizing blockade?
Succinylcholine. Strong ACh agonist
Phase I: prolonged depol
Phase II: repolarized but blocked (receptors desensitized)
AChE inhibitors - effect on Phase I and II?
Phase I: potentiates block
Phase II: reverses block
Complications of depolarizing blockade?
HyperCa, HyperK, malignant hyperthermia
Non-depolarizing blockade - drug suffixes (exception), and MoA
-curonium (and tubcurarine); compete with ACh for receptors
Reverse non-depolarizing blockade with?
Neostigmine, edrophonium (AChE inhibitors)
MoA of drug used in malignant hyperthermia and neurleptic malignant syndrome?
Dantrolene. Prevents release of Ca from sarcoplasmic reticulum of skeletal muscle.
Drugs that can trigger malignant hyperthermia?
inhalation anesthetics (except N2O) and succinylcholine
PD drugs - DA agonists?
Ergot - Bromocriptine
non-ergot - pramipexole, ropinirole
PD drugs - Other use for drug that increases DA?
Amantadine. Antiviral against influenza A and rubella.
PD drugs - converted to DA?
PD drugs - MoA of drug that prevents DA breakdown centrally?
Selegiline. MAO-B inhibitor
Entacapone, tolcapone (COMT inhibitors - prevent dopa degradation)
PD drugs - Class of drug that curbs excess ACh?
(PARK the BENZ)
For essential tremors, use?
Full DA treatment?
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
MoA of drug given with L-dopa?
carbidopa - peripheral decarboxylase inhibitor. Prevents conversion of L-dopa to carbidopa in periphery
Long term use can lead to dyskinesia with doses and akinesia between doses?
increased peripheral DA can lead to?
MoA of drug that may enhance the adverse effects of L-dopa?
Selegiline (inhibits MAO-B)
ALZ pt comes in with dizziness, confusion, hallucinations. Mech of Drug with these side effects?
Memantine. NMDA antag - precents Ca excitotoxicity
ALZ pit takes drug can won't go to sleep. Also has nausea and dizzines. MoA of drugs?
Donepezil, galantamine, rivastigmine. AChE inhibitors.
Pt with decreased GABA, decreased ACh and increased DA. Goal of treatment? Drugs
Huntington's - decrease DA.
Tetrabenazine and reserpine - inhibit VMAT (decrease DA packaging)
Haloperidol (DA receptor antag)
MoA for Drug for acute migraine.
Sumatriptan. 5HT1b/1d agonist.
1)Inhibits trigeminal nerve activation
2) prevents vasoactive peptide release
3) induces vasoconstriction
Pt with chronic episodes of pain comes in with coronary vasospasm and tingling. Drug that could have caused it?