Neuromuscular Junction and Muscle Disorders Flashcards Preview

aNeuro Exam I- Lindsey's > Neuromuscular Junction and Muscle Disorders > Flashcards

Flashcards in Neuromuscular Junction and Muscle Disorders Deck (14):
1

Myasthenia Gravis (MG) is a _____ disorder associated with a post-junctional defect of the AChR.

autoimmune

2

Myasthenia Gravis (MG) is an autoimmune disorder associated with a ______.

post-junctional defect of the AChR

3

Who is more likely to get MG?

women

4

What are the s/s of MG?

  • weakness
  • fatigue
  • ptosis
  • diplopia (double vision)
  • blurred vision
  • slurred speech
  • trouble chewing and swallowing

5

Dx?

  • weakness
  • fatigue
  • ptosis
  • diplopia (double vision)
  • blurred vision
  • slurred speech
  • trouble chewing and swallowing

Myasthenia Gravis (MG)

6

How is diagnosis of MG confirmed?

+ AChR antibodies in the serum

7

What medication is given to treat MG specifically and why?

Pyridostimine- it's an oral AChE inhibitor

8

With management, the majority of MG pts have a _____ quality of life.

excellent

9

How does a pt get muscular dystrophy?

it's X-linked recessive

10

What is Becker dystrophy (BD)?

It is muscular dystrophy, but unlike Duchenne's, it has:

  • later onset
  • more benign course
  • longer survival
  • less mental impairment

11

Which muscular dystrophy type?

  • later onset
  • more benign course
  • longer survival
  • less mental impairment

Becker dystrophy (BD)

12

Dx?

  • clumsy waddling gait
  • protruberant abdomen
  • lumbar lordosis
  • enlargement of the calves
  • Gower's maneuver

Duchenne Muscular Dystrophy (DMD)

13

How is Duchenne Muscular Dystrophy (DMD) diagnosed?

  • markedly elevated serum CK
  • DNA testing

14

What are the 3 common mutation types in DMD?

  1. deletions
  2. duplications
  3. point mutations