Flashcards in Neuron Physiology Deck (31):
simultaneous stimulation of multiple synapses located near each other
Repetitive stimulation of the same channel, altering the membrane potential before it can return to normal
Change in the cells membrane potential that makes it more negative
Calciums role in synaptic transmission
Triggers release of neurotransmitters from the storage vesicle. Enter through the voltage gated calcium channels after an action potential occurs.
Excitatory Ion Channels
Have sodium channels
Neurotransmitters: Ach and glutamate
Inhibitory Ion channels
receptors have chloride channels
Neurotransmitters: GABA, glycine
-several functions, slow and long lasting
Neurotransmitters: Dopamine, Serotonin, Ach, Norepinephrine
Excitatory Post Synaptic Potential (EPSP)
Sodium influx causes a less negative potential
Inhibitory Post Synaptic Potential (IPSP)
Increased NEGATIVE potential due to the out flux of potassium and/or influx of chloride
Primary neurotransmitters in the peripheral nervous system
At rest, a neurons membrane potential will be closest to the equilibrium potential of what ion?
What neurotransmitter binds to AMPA, Kainate, and NMDA receptors?
Influx of what ion into the cell can lead to hyper polarization?
Chloride, seen in inhibitory ion channel receptors such as GABAa.
Example of de-myelnation in the CNS
Example of de-myelanation in the PNS
Epi, NE, Dopamine
Amino acid neurotransmitters
GABA, Glutamate, Glycine
GCPR and usually inhibitory
Where is epinephrine released in the sympathetic nervous system?
the adrenal medulla
Multiple GCPR, one Ion channel
MAOIs increase levels of all___?
Three antidepressants that target serotonin
MAOI's, Tricyclics, SSRIs
Major EXCITATORY NT in the CNS
Doesn't cross the BBB
Uses GCPR and ion channels
Major inhibitory neurotransmitter in the CNS
GABAa and GABAc are why type of receptors?
Inhibitory ion channels. Influx of Cl- leads to hyperpolarization
GABAb is what type of receptor?
It inhibits adenyl cyclase and calcium influx
What is the major NT at the neuromuscular junction?
Nicotinic receptors (excitatory and/or inhibitory?) (Ion channel or GCPR?)
Excitatory, Ion channel
Muscarinic receptors (excitatory and/or inhibitory?) (Ion channel or GCPR?)
Excitatory and inhibitory, GCPR