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Flashcards in Neuron Physiology Deck (31):
1

Spatial Summation

simultaneous stimulation of multiple synapses located near each other

2

Temporal summation

Repetitive stimulation of the same channel, altering the membrane potential before it can return to normal

3

Hyperpolarization

Change in the cells membrane potential that makes it more negative

4

Calciums role in synaptic transmission

Triggers release of neurotransmitters from the storage vesicle. Enter through the voltage gated calcium channels after an action potential occurs.

5

Excitatory Ion Channels

Have sodium channels
Neurotransmitters: Ach and glutamate

6

Inhibitory Ion channels

receptors have chloride channels
Neurotransmitters: GABA, glycine

7

GCPR

-several functions, slow and long lasting
Neurotransmitters: Dopamine, Serotonin, Ach, Norepinephrine

8

Excitatory Post Synaptic Potential (EPSP)

Sodium influx causes a less negative potential

9

Inhibitory Post Synaptic Potential (IPSP)

Increased NEGATIVE potential due to the out flux of potassium and/or influx of chloride

10

Primary neurotransmitters in the peripheral nervous system

Ach, NE

11

At rest, a neurons membrane potential will be closest to the equilibrium potential of what ion?

Potassium (-90mV)

12

What neurotransmitter binds to AMPA, Kainate, and NMDA receptors?

Glutamate

13

Influx of what ion into the cell can lead to hyper polarization?

Chloride, seen in inhibitory ion channel receptors such as GABAa.

14

Example of de-myelnation in the CNS

Multiple sclerosis

15

Example of de-myelanation in the PNS

Guillain-barre syndrome

16

monoamines (catecholamines)

Epi, NE, Dopamine

17

Monoamines (indoleamines)

serotonin

18

Amino acid neurotransmitters

GABA, Glutamate, Glycine

19

Dopamine Receptors

GCPR and usually inhibitory

20

Where is epinephrine released in the sympathetic nervous system?

the adrenal medulla

21

Serotonin receptors

Multiple GCPR, one Ion channel

22

MAOIs increase levels of all___?

Monoamines

23

Three antidepressants that target serotonin

MAOI's, Tricyclics, SSRIs

24

Glutamate

Major EXCITATORY NT in the CNS
Doesn't cross the BBB
Uses GCPR and ion channels

25

GABA

Major inhibitory neurotransmitter in the CNS

26

GABAa and GABAc are why type of receptors?

Inhibitory ion channels. Influx of Cl- leads to hyperpolarization

27

GABAb is what type of receptor?

GCPR
It inhibits adenyl cyclase and calcium influx

28

What is the major NT at the neuromuscular junction?

Ach

29

Nicotinic receptors (excitatory and/or inhibitory?) (Ion channel or GCPR?)

Excitatory, Ion channel

30

Muscarinic receptors (excitatory and/or inhibitory?) (Ion channel or GCPR?)

Excitatory and inhibitory, GCPR

31

What are two neuropeptides?

Vasopressin and oxytocin
-prolonged action
-synthesized in rough ER