Neurophysiology Flashcards
Photon energy is absorbed by cis-retinal. Isomerization to trans-retinal, seperation from opsin and enzyme activation
- when photopigments are stimulated by light
What does it mean if there is no reaction in any dermatome caudal to T12 ?
- spinal CORD damage at T12 level
Spinal Cord Lesion affect on proprioception
- sensory ataxia
- > deficit in postural reactions and/or gait
Pathway for Touch
- spinothalamic pathway
- touch sensitive neurons enter the dorsal column and ascend to the somato-sensory cortex
- > same pathway as conscious proprioception!
Lesion in the retina, optic nerve, optic chiasm and optic tracts results in?
- vision and PLR deficits
What is affected for a lesion in the dorsal column?
- gait is largely normal
- postural responses are affected
What does the cutaneous trunci reflex test?
- the integrity of a long spinal cord segment from C8/T1 - L4/5
What contains the crista in its ampulla?
- the 3 semi-circular canals
Where is the reticular activation system (RAS) located?
- in the thalamus
Incoordinated gait and/or postural responses WITHOUT loss of muscle strength (without paresis/paralysis)
- sensory ataxia
Second Pain
- “Maintenance of pain”
- activated nociceptors release additional chemicals
- > substance P and calcitonin gene related peptide (CGRP)
- causes more pain and releases inflammatory mediators (inflammatory soup)
- Activates a different set of nociceptors and maintain a burning, nagging, throbbing, etc lasting pain sensation via un-myelinated C fibers
First step when evaluating a neurological patient?
- determine the site of the lesion
- > lesion localization
- followed by diagnostic procedures
Where do upper motor neurons originate and run?
- originate in the brain (cortex and brainstem)
- descends in the lateral and ventral funiculi
- stimulate and inhibit lower motor neurons in the ventral gray horn
Conscious Proprioception
- purposeful
- learned/skilled movements
- fine motor skills
What does the brainstem consist of?
- Mesencephalon = Midbrain (CN III and IV)
- Metencephlon = Pons (CN V) with Cerebellum
- Myelencephalon = Medulla oblongata (CN VI-XII)
Field seen by one eye, large monocular fields enable good surveillance of the external world. Good for prey animals.
- Monocular (peripheral) vision
- > Horses have large ones and a very small binocular area
Unconscious proprioception pathway
- Spinocerebellar Tract
- important for the coordination of automated movements, or gait (gross motor skills)
- ascend in several tracts in the lateral funiculus and terminate in the ipsilateral cerebellum
When are spinal cord fibers more vulnerable to damage?
- the more superficially they are located and the more they are myelinated
What does damage to the vestibular system typically effect?
- balance system and eye movements
1. Head tilt (towards lesion)
2. Circling or rolling (towards lesion)
3. Pathological nystagmus (slow phase towards the site of the lesion)
4. Feeling of vertigo (in humans)
What is the analgesia pathway activated by?
- activated by incoming pain, also by high sympathetic tone, excitement, danger, etc
Every 3rd order neuron ends in a designated location of the cortex, aka each area is dedicated to the perception of one sense. This is called the?
- cortical map
Every part of the body is projected to a specific location within its respective cortex area
- point to point mapping (body to cortex)
- > more important body parts are over represented
Spinothalamic tract synapses with the 3rd order neurons in the thalamus and projects to which brain regions
- Somatosensory Cortex
- input from A delta fibers = acute pain/localized pain - Reticular Formation/Limbic System
- input from C fibers
- dull, aching, burning pain/autonomic responses/emotional and behavioral responses
Contains melanin to absorb stray light and to prevent light scattering for sharper images
- pigment epithelium of the retina
Maintenance of body position in relation to the force of gravity
- static equilibrium
- > registers head tilt and linear movement
An exaggerated pain response to a noxious stimulus
- hyperalgesia
What are the sound receptors of the ears?
- hair cells
Amygdala Highjack
- the limbic system links strong emotions with visceral/autonomic nervous system reactions via the hypothalamus without higher brain involvement
What does it mean if there is no reaction in 1 autonomous zone?
- plexus nerve damage
What are the tip links of hair cells connected to?
- mechanically gated K channel
Damage to extra-pyramidal systems have what signs?
- muscle weakness with spastic paresis/paralysis
- hyperreflexia
- slow muscle altrophy
- > variable signs from complete paralysis to mild gait deficits and postural response deficits (motor ataxia)
Contains photoreceptors, bipolar cells and ganglion cells
- neural epithelium of the retina
Series of high and low-pressure regions traveling in the same direction within a medium (mechanical energy)
- sound waves
What is responsible for seat of consciousness, wakefulness and sleep?
- Reticular formation, RAS and Thalamus
Pathological pain, or Bad pain. It serves no physiological purpose and persists in the absence of tissue injury
- chronic pain
-> hypersensitivity of the pain transmission system
Ex: hyperalgesia and allodynia
G-protein coupled signaling pathway purpose
- transduction of light energy into electrical energy
- > photopigments of rods/cones undergo a conformational change when absorbing light energy
The pyramidal system is very important and well developed in which species?
- primates
What happens when a tactile/pain receptor within a dermatome is stimulated?
- impulses enter spinal cord via spinal nerve
- transmission to CNS via conscious proprioception via dorsal column/STT
- Simultaneously, at level C8/T1, collaterals activate the motor neurons innervating the cutaneous trunci muscle causing it to twitch
What is responsible for the conscious experience of the incoming sensory information?
- cerebral cortex
What happens if there is damage to a spinal or plexus nerve?
- loss of touch/pain sensation in the relevant dermatome, or autonomous zone
- > animal shows no reaction
Spinal Cord Lesion affect on Voluntary motor control
- Motor ataxia
- > UMNs signs, paralysis
If there is damage to the pyramidal system in primates what would you see?
- typical upper motor neuron signs
- > facial and arm/hand muscles (stroke)
Central Sensitization
- “Wind up”
- hyperexcitability of neurons at synapses within the CNS (neuropathic pain) upon strong stimulation
Initiated by changes in light intensity to control the amount of light falling onto the retina
- pupillary light reflex
What is the vestibular organ responsible for?
- sense of balance
A specialized transmitter, receiver sensory system of high frequency sound to locate objects
- echolocation
- > animal hears a three dimensional picture of its surroundings
What do hair cells synapse with?
- first order sensory neurons of the vestibulocochlear nerve
Pathway for Touch
- touch sensitive neurons enter the dorsal column and ascend to the somato-sensory cortex
- > same pathway as conscious proprioception!
What is phantom pain caused by?
- hyperactive neuromas at the amputation site
What are hair cells embedded in during dynamic equilibrium?
- gelatinous cupula
Visual Pathway - Draw and name
- Axons exit at optic disc as the optic nerve
- In the optic chiasm
- fibers from nasal portions of retina (Peripheral vision) cross over
- fibers from the temporal portions of retina (central vision) stay ipsilateral - Optic tract
- Thalamus
- Optic striations
- Visual cortex
Reflection of Sound
- sound is reflected by objects and is perceived via mandibles (inner ear)
Purpose of the photopigments (rods and cones)
- absorb the incoming light energy
- > are receptor molecules
Where adjacent receptive fields overlap to allow precise localization
- sensory field
What are hair cells cilia connected to each other by?
- Tip links
What innervates the cutaneous trunci muscle?
- the lateral thoracic nerve from spinal cord segments C8, or T1
What happens during linear acceleration?
- the otolithic membrane lags behind the actual movement due to its inertia
- > hair bundles bend in the opposite direction to the movement
Neurons originate in the brain stem, immediately cross over or dont and activate/inhibit the LMNs of limbs, trunk and neck
- extra-pyramidal system
Draw the stick figure man
- did you get it right finally?
Which, rods OR cones, have more photopigments and are stimulated by a single photon
- rods
- > very sensitive
- > regenerate slowly, therefore not suitable for strong light conditions
Which photopigment is involved in night vision vs day vision?
- Night vision = rods
2. Day vision = cones
How does sound transduction occur?
- waves of the basilar membranes push the spiral organ and hair cells against or away from the tectorial membrane, causing electrical changes
The section of tissue innervated by one sensory neuron is called?
- receptive field
Forebrain lesion
- Mental status = depression
- Behavior = altered
- Seizures = because hyperactivity of cortical neurons
What happens when hair cells deviate towards each other and there is movement towards the tectorial membrane?
- relaxes the tip links
- closes K channels
- hyperpolarization
- AP frequency decrease
Loudness effects
- the louder the sound, the larger the deviation and the higher the AP frequency
- > can lead to permanent hair cell damage