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Neuroanatomy > NM Pharmacology > Flashcards

Flashcards in NM Pharmacology Deck (11):
1

nAChR Subs (3)

Neuronal: alpha and beta
Muscle: fetal - a/b/g/d. Adult - a/b/e/d

2

ACh Binding Protein

Buffers amount of ACh in synapse bc looks like outside of AChR but is soluble

3

Sequence of Muscle Blockade

Fast twitch first - tips of extremities
Limbs/neck/trunk
Intercostals/diaphragm - respiratory failure. Helpful that that's last

4

Side Effects from Competitive Blockers like DTC (d-tubocurarine) (2)

No CNS effects bc don't cross BBB
Hypotension due to ganglionic blockade and histamine release

5

Succinylcholine (what it is, 2 phases, important point about treatment, and complication)

Looks like 2 ACh, can't by hydrolyzed so continuously activate R
Phase I (depolarizing) - R activation and depol, then fasciculations, then flaccid paralysis
Phase II (desensitizing) - membrane repolarizes, but doesn't respond to nerve stimulation bc Rs are desensitized (or channel blocked)
Don't treat w/ neostigmine bc problem is not lack of ACh
Malignant Hypothermia can occur

6

Edrophonium

Short duration, reversible inhibitor of AChE

7

Carbamate Esters

Like neostigmine, covalent very slowly reversible inhibitors of AChE

8

Organophosphates

Like malathion and sarin, covalent irreversible inhibitors of AChE

9

2-PAM

Treats OP toxicity as long as administered before "aging"

10

How to Test Neostigmine Dose for MG

Give edrophonium. If strength increases, not enough. If it weakens, too much

11

Physostigmine

Treatment for atropine intoxication, AChE inhibitor that crosses BBB unlike neostig