Flashcards in NMB Agents Deck (12):
Succinylcholine - speed of action
Rapid on & offset
metabolized by pseudocholinesterases, people with atypical plasma pseudocholinesterases have extended clinical effects
How does sux work?
Binds, depolarizes and non-competitively inhibits acetylcholine receptors at NMJ
Fascilations which which drug?
Side effect of sux?
Transient increase in plasma potassium level, related to number of ACh receptors at NMJ, those with increased receptors at NMJ are at higher risk for hyperkalemia (like those with spinal cord injury), burns, immobility, NM disorder such as MD, but can be given in patients with renal failure if they have normal K
Competitive antagonists, rocuronium, mivacurium, pancuronium, cisatracurium
Fast onset NMB
NMB that causes tachycardia by vagolysis
How are most NMBs degraded?
Degrases spontaneously in plasma - good for liver or kidney failure
Reversal of non-depolarizing NMBs
Neostigmine or edrophonium (Achesterase inhibitors) If you increase concentration of acetylcholine in NMJ you can clinically reverse effects of NMB, patient must have at least one visible twitch, then give acetylcholinesterase inhibitor