Non-benzo anxiolytics Flashcards Preview

Cology 2 Exam 1 > Non-benzo anxiolytics > Flashcards

Flashcards in Non-benzo anxiolytics Deck (13):
1

How do 5HT-1A partial agonists work? How long do they take to work?

Work mostly at presynaptic receptors (act as an agonist or antagonist depending on serotonin levels)
Decreases serotonin and dopamine transmission

Anxiolytic actions take weeks to develop fully
Could possibly require up/down regulation of serotonin receptors

2

Benefits of 5HT-1A partial agonists over BDZ's?
Adverse effects?

No sedation, less interaction with other sedatives
No tolerance or withdrawal

Adverse effects: Dizziness, restlessness, nausea, headache, seizures

3

Can 5HT-1A agonists be used with BDZ's?

Yes in Generalized anxiety disorder (synergistic effect)

4

Can 5HT-1A agonists be used with SSRI's?

Yes in Mixed anxiety/depression (synergistic effect)

5

5HT-1A agonists are not useful in what disorders

Panic disorder, social phobias, OCD, PTSD

6

What are examples of 5HT-1A partial agonists

Buspirone
Gepirone

7

How does Buspirone work

5HT-1A partial agonist
Decrease 5-HT and dopamine transmission
Anxiolytic without sedation
Takes weeks!

8

How does Gepirone work

5HT-1A partial agonist
Decrease 5-HT and dopamine transmission
Anxiolytic without sedation
Takes weeks!

9

How does Ondansetron work?

5-HT3 antagonist
Works post-synapticly, directly blocks 5-HT transmission

10

Which drug class is only effective for performance anxiety?

Beta blockers
Decreases anxiety-induced sympathetic activation

11

How does Clonidine work?

Anxiolytic that decreases norepinephrine release via autoreceptor activation
Works at Presynaptic receptors

12

How do CCK antagonists work?

They are non-peptide analogs
That's all she gave us lol

13

How does Oxytocin work?

Decreases ethanol withdrawal-induced anxiety
Given intranasally