Non-Lymphocyte Leukocytes

Question 1

most abundant WBC in circulation

Answer 1

neutrophils

Question 2

contain multilobed nuclei

Answer 2

neutrophils

Question 3

most common polymorphonuclear cells

Answer 3

neutrophils

Question 4

indicator of acute inflammation

Answer 4

neutrophils

Question 5

neutrophils are attracted to inflammation sites via

Answer 5

C5a, leukotriene B4, IL-8

Question 6

functions of neutrophils

Answer 6

phagocytosis
degranuation
oxidative burst

Question 7

Neutrophil granules

Answer 7

Myeloperoxidase
Elastase
Lysozyme
NADPH oxidase
Lactorferrin

Question 8

produces reactive oxygen species

Answer 8

neutrophil oxidative burst

Question 9

ROS

Answer 9

superoxide
hydrogen peroxide
hypochlorite (bleach)

Question 10

superoxide is produced by

Answer 10

NADPH oxidase

Question 11

Chronic granulomatous disease is caused by

Answer 11

NADPH oxidase deficiency

Question 12

hydrogen peroxide is produced by

Answer 12

superoxide dismutase (SOD)

Question 13

hydrogen peroxide is degraded by

Answer 13

catalase

Question 14

hypochlorite (bleach) is produced by

Answer 14

myeloperoxidase

Question 15

activate after binding to IgE

Answer 15

basophils

Question 16

basophil activation leads to the release of

Answer 16

histamine, heparin

Question 17

mediate allergy/anaphylaxis

Answer 17

basophils

Question 18

recruited by IL-5

Answer 18

eosinophils

Question 19

releases major basic protein when activated

Answer 19

eosinophils

Question 20

activated by Fc regions of antibodies

Answer 20

eosinophils

Question 21

toxic to parasitic worms

Answer 21

eosinophils

Question 22

contribute to allergy/asthma

Answer 22

eosinophils

Question 23

inhibited by corticosteroids

Answer 23

eosinophils

Question 24

activated by tissue trauma, anaphylatoxins, IgE, vancomycin

Answer 24

mast cells

Question 25

mast cell degranulation leads to the release of

Answer 25

histamine, heparin, tryptase

Question 26

special name for macrophage in blood

Answer 26

monocyte

Question 27

activated by IFN-y

Answer 27

macrophage

Question 28

produced by Th1 cells

Answer 28

macrophage

Question 29

produces TNF-a, IL-1, IL-6, IL-8, IL-12

Answer 29

macrophage

Question 30

phagocytosis of bacteria, cellular debris, or senescent RBCs

Answer 30

macrophages

Question 31

releases elastase or metalloproteinases

Answer 31

macrophage

Question 32

APC vis MHC II

Answer 32

macrophages

Question 33

major component of granulomas

Answer 33

macrophage

Question 34

expresses CD14

Answer 34

macrophages

Question 35

CD14

Answer 35

receptor for LPS

Question 36

stimulated by IL-2, IL-12, and type 1 IFNs

Answer 36

NK

Question 37

activated by cells lacking MHC I

Answer 37

NK

Question 38

kills tumor or viral cells

Answer 38

NK

Question 39

activated by cells bound with IgG

Answer 39

NK

Question 40

antibody dependent cell mediated cytotoxicity (ADCC)

Answer 40

CD16 express on NK cells binds to Fc region of bound IgG, activating NK cell

Question 41

activation releases granules containing perforin and granzyme

Answer 41

NK

Question 42

perforin

Answer 42

forms pores in target cell membrane

Question 43

granzymes

Answer 43

enters through perforin pores to induce cell death

Question 44

professional antigen producing cells

Answer 44

dendritic cells

Question 45

constitutively express MHC II and B7

Answer 45

dendritic cells

Question 46

needed for CD4 activation

Answer 46

dendritic cells

Question 47

link innate and adaptive immune response

Answer 47

dendritic cells

Question 48

dendritic cells are called _______ in skin

Answer 48

Langerhans