Nonneoplastic Hematologic Disorders Flashcards

(176 cards)

1
Q

1.Which one of the following types of hemoglobins has α2β2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above

A

A. Hemoglobin A (HbA)

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2
Q

Which one of the following types of hemoglobins has α2γ2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above

A

B. Hemoglobin F (HbF)

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3
Q

Which one of the following types of hemoglobins has α2δ2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above

A

C. Hemoglobin A2 (HbA2)

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4
Q

Sickle cell disease is most common in:
A. African Americans
B. Asian Indians
C. Hispanic Americans
D. Middle Easterners
E. Native Americans
F. Northern Europeans

A

A. African Americans

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5
Q

Which one of the following assays is NOT used as the test of choice for SCD in the NBS in the United States?
A. Electrophoresis
B.High-performance liquid chromatography (HPLC)
C.Isoelectric focusing (IEF) electrophoresis D.Sanger sequencing of HBB
E.None of the above

A

D.Sanger sequencing of HBB

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6
Q

SCD is caused by a mutation in:
A. HBA1
B. HBA2
C. HBA
D. HBB1
E. HBB2
F. HBB

A

F. HBB

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7
Q

Wife with SCD brother and Caucasian husband What would be the risk of their firstborn child having SCD?
A. 100%
B. 50%
C. 25%
D. <1%
E. Can’t predict

A

D. <1%

wife 2/3
Caucasian <1%

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8
Q

Which one of the following is the most common pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in patients with sickle cell disease (SCD) by age 6 weeks?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above

A

D. HbS and HbF

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9
Q

SCD. Which one of the followings following would most likely be the pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in this patient’s peripheral-blood sample?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above

A

D. HbS and HbF

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10
Q

The medical history showed that the patient had HbSS. Which one of the following would most likely be the pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in this patient’s peripheral-blood sample?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above

A

D. HbS and HbF

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