Nonneoplastic Hematologic Disorders Flashcards
(176 cards)
1.Which one of the following types of hemoglobins has α2β2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above
A. Hemoglobin A (HbA)
Which one of the following types of hemoglobins has α2γ2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above
B. Hemoglobin F (HbF)
Which one of the following types of hemoglobins has α2δ2?
A. Hemoglobin A (HbA)
B. Hemoglobin F (HbF)
C. Hemoglobin A2 (HbA2)
D. Hemoglobin S (HbS)
E.None of the above
C. Hemoglobin A2 (HbA2)
Sickle cell disease is most common in:
A. African Americans
B. Asian Indians
C. Hispanic Americans
D. Middle Easterners
E. Native Americans
F. Northern Europeans
A. African Americans
Which one of the following assays is NOT used as the test of choice for SCD in the NBS in the United States?
A. Electrophoresis
B.High-performance liquid chromatography (HPLC)
C.Isoelectric focusing (IEF) electrophoresis D.Sanger sequencing of HBB
E.None of the above
D.Sanger sequencing of HBB
SCD is caused by a mutation in:
A. HBA1
B. HBA2
C. HBA
D. HBB1
E. HBB2
F. HBB
F. HBB
Wife with SCD brother and Caucasian husband What would be the risk of their firstborn child having SCD?
A. 100%
B. 50%
C. 25%
D. <1%
E. Can’t predict
D. <1%
wife 2/3
Caucasian <1%
Which one of the following is the most common pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in patients with sickle cell disease (SCD) by age 6 weeks?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above
D. HbS and HbF
SCD. Which one of the followings following would most likely be the pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in this patient’s peripheral-blood sample?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above
D. HbS and HbF
The medical history showed that the patient had HbSS. Which one of the following would most likely be the pattern of hemoglobins identified by high-performance liquid chromatography (HPLC) in this patient’s peripheral-blood sample?
A.HbS, HbA2, HbF, and HbA
B.HbS, HbF, and HbA
C.HbS, HbA2, and HbF
D. HbS and HbF
E.HbS, HbF, and HbC
F.None of the above
D. HbS and HbF