Noradrenaline neurons are located mainly in…
locus coeruleus - involved in activity lvls, cognition, mood, emotion and movement
NA + Depression
decreased NA transmission from locus coeruleus + caudal raphe nuclei (principle NA centres)
NA projections from LC to Frontal Cortex = …
mood regulation
~ involves beta1 postsynaptic receptors
NA projections from LC to Frontal Cortex = … 2
attention, working memory, concentrations
~ alpha2 postsynaptic receptors
NA projections from LC to Limbic Cortex = …
emotion, energy
NA projections from LC to Cerebellum = …
motor movements e.g. tremor
Name the three areas that NA neurones project to from LC.
1) frontal cortex
2) limbic cortex
3) cerebellum
NA deficiency causes… (4)
~ impaired attention + concentration
~ fatigue
~ depressed mood
~ slow info. processing
How can NA action be terminated?
~ by enzymes e.g. MAO
~ reuptake
Serotonin is synthesised in…
…raph nuclei + is then sent throughout the entire CNS
Name the three areas that serotonergic neurones project to from LC.
1) frontal cortex
2) limbic areas
3) hypothalamus
Serotonergic projections from RN to Frontal Cortex = …
regulating mood
Serotonergic projections from RN to Limbic Areas = …
anxiety + panic
Serotonergic projections from RN to Hypothalamus = …
appetite + eating behaviour
Name two other areas where serotonergic neurons are found.
1) brain stem (sleep)
2) spinal cord (sexual response)
