Noradrenaline + Serotonergic System

Question 1

Noradrenaline neurons are located mainly in…

Answer 1

locus coeruleus - involved in activity lvls, cognition, mood, emotion and movement

Question 2

NA + Depression

Answer 2

decreased NA transmission from locus coeruleus + caudal raphe nuclei (principle NA centres)

Question 3

NA projections from LC to Frontal Cortex = …

Answer 3

mood regulation

~ involves beta1 postsynaptic receptors

Question 4

NA projections from LC to Frontal Cortex = … 2

Answer 4

attention, working memory, concentrations

~ alpha2 postsynaptic receptors

Question 5

NA projections from LC to Limbic Cortex = …

Answer 5

emotion, energy

Question 6

NA projections from LC to Cerebellum = …

Answer 6

motor movements e.g. tremor

Question 7

Name the three areas that NA neurones project to from LC.

Answer 7

1) frontal cortex
2) limbic cortex
3) cerebellum

Question 8

NA deficiency causes… (4)

Answer 8

~ impaired attention + concentration
~ fatigue
~ depressed mood
~ slow info. processing

Question 9

How can NA action be terminated?

Answer 9

~ by enzymes e.g. MAO

~ reuptake

Question 10

Serotonin is synthesised in…

Answer 10

…raph nuclei + is then sent throughout the entire CNS

Question 11

Name the three areas that serotonergic neurones project to from LC.

Answer 11

1) frontal cortex
2) limbic areas
3) hypothalamus

Question 12

Serotonergic projections from RN to Frontal Cortex = …

Answer 12

regulating mood

Question 13

Serotonergic projections from RN to Limbic Areas = …

Answer 13

anxiety + panic

Question 14

Serotonergic projections from RN to Hypothalamus = …

Answer 14

appetite + eating behaviour

Question 15

Name two other areas where serotonergic neurons are found.

Answer 15

1) brain stem (sleep)

2) spinal cord (sexual response)