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Flashcards in Novel Antidepressants Deck (28):
1

Novels represent the...

Newest Antidepressants!!

2

This drug blocks the reuptake of Dopamine & Norepinephrine (NDRI)

Bupropion

3

Daily dose range for Bupropion: (x3)

150-450

4

These unpleasant side fx are uncommon on bupropion:

Anticholinergic, Sex disturb & hypotension, sedation

5

Bupropion can produce these 3 at high doses.

Agitation
Headache
Seizures

6

This drug is the most prescribed, selectively inhibiting both 5Ht & NE (SNRI) Dose range?

Venlafaxine! 75-375mg

7

The major plus of Venlafaxine is that it:

Lacks any sexual, antiochlinergic, sedation or hypotension.

8

The major negative of Venlafaxine is:

Nausea, can be severe.

9

T/F Nausea w/ Venlafaxine will become tolerated.

TRUE

10

At high doses of Venlafaxine, the patient may report:

Hypertension

11

T/F Venlafaxine potentiates many drugs.

FALSE - not a strong inhibitor of liver enzymes.

12

This little ditty is a metabolite of Venlafaxine:

Desvenlafaxine

13

Dose range? Most respond around:

50-100 (50)

14

Desvenlafaxine has a big one up on Venlafaxine in that it doesn't produce:

Nausea

15

This drug increases NE & 5HT release by blocking the normal braking system.

Mirtazapine

16

This leads to a new way to alter NT activity. The 3 now are:

Reuptake
Deactivation
Autoreceptor Antagonism

17

In addition, Mirtazapine has a minor ability to:

Block reuptake of 5HT & NE

18

Mirtazapine is also useful in treating:

Anxiety

19

Most common side fx of Mirtazapine are: (6)

Dry mouth
Constipe/Weight gain
Drowsiness/Sedation
& Hypotension

20

These side fx are caused by:

Blockade of acetylcholine & alpha adrenergic receptors

21

Mirtazapine has a lowered risk of:

Sexual Dysfunction

22

Dosing regimen for Mirtazapine:

15mg x 4 days ->
30 mg x 10 days ->
45 mg

23

This drug increases NE & 5HT by inhibiting the reuptake process.

Duloxetine (Cymbalta)

24

Duloxetine is also useful in treating:

Anxiety Disorders & Neuropathic Pain

25

Oral daily dose range for Duloxetine is:

40-60mg

26

Common side fx include: (7)

GI - NVD, Reduced appetite
Constipe
Sweating
Drowsiness/Somnolence
Tachycardia & Hypertension

27

Duloxetine has an interaction with NSAIDS in that it:

Increases risk of bleeding

28

When used with other antidepressants, we run the risk of:

Serotonin Syndrome