NSAIDs/DMARDS

Question 1

Toradol

Answer 1

Ketorolac

NSAID

used for moderate post-surgical pain up to 5 days

Question 2

Motrin

Answer 2

Ibuprofen

NSAID

Question 3

Aleve/Naprosyn

Answer 3

Naproxen

NSAID

Question 4

Orudis

Answer 4

Ketoprofen

NSAID

Question 5

Indocin

Answer 5

Indomethacin

NSAID

used for gout

Question 6

Feldene

Answer 6

Piroxicam

NSAID

long half-life, high risk for GI ulcers

Question 7

Clinoril

Answer 7

Sulindac

NSAID

Question 8

Lodine

Answer 8

Etodolac

NSAID

COX-2 selective

Question 9

Mobic

Answer 9

Meloxicam

NSAID

COX-2 selective

Question 10

Relafen

Answer 10

Nabumetone

NSAID - COX-2 selective

Prodrug, long half-life

Question 11

Voltaren

Answer 11

Diclofenac

NSAID

COX-2 selective

Question 12

Celebrex

Answer 12

Celecoxib

NSAID - COX-2 selective

CV risk

Question 13

Nalfon

Answer 13

Fenoprofen

NSAID

Question 14

Ansaid

Answer 14

Flurbiprofen

NSAID

Question 15

Daypro

Answer 15

Oxaprozin

NSAID

Question 16

Rheumatrex

Answer 16

Methotrexate

DMARD

inhibits proliferation and stimulates apoptosis of immune-inflammatory cells
Folic acid antagonist - don’t take folic acid on same day as Methotrexate

ADR - N/V/D, leukopenia, teratogenic, thrombocytopenia,

Question 17

Plaquenil

Answer 17

Hydroxychloroquine

DMARD

inhibits t-lymphocyte responses, leukocyte chemotaxis, DNA/RNA synthesis
stabilization of lysosomal enzymes
trapping of free radicals

ADR - N/V/D, rash, ocular toxicity, alopecia (spot balding)

Question 18

Azulfidine

Answer 18

Sulfasalazine

DMARD

suppresses t-cell response
inhibits b-cell proliferation, cytokine release

ADR - N/V/D, rash, leukopenia, alopecia, elevated liver enzymes

Question 19

Arava

Answer 19

Leflunomide

DMARD

suppresses t-cell response
inhibits b-cell proliferation, cytokine release

ADR - Diarrhea, alopecia, leukopenia, thrombocytopenia, teratogenic

Question 20

Enbrel

Answer 20

Etanercept

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

Question 21

Humira

Answer 21

Adalimumab

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

Question 22

Remicade/Inflectra

Answer 22

Infliximab

DMARD biologic - TNF-alpha inhibitor

inhibits TNF-alpha function

Uses:
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriatic Arthritis
Crohn's Disease

ADR - injection site reactions, lupus-like syndrome, increased risk of infection/malignancy, HF exacerbation, neurologic demyelinating syndromes

Question 23

Colcrys

Answer 23

Colchicine

inhibits leukocyte migration and phagocytosis

ADR - N/V/D, abdominal pain

Question 24

Benuryl

Answer 24

Probenecid

Uricosuric agent

organic acids that inhibit reabsorption of uric acid in proximal tubule

ADR - Gi upset, rash, renal stones

Question 25

Zyloprim

Answer 25

Allopurinol Inhibits xanthine oxidase, preventing the conversion of hyoxanthine and xanthine to uric acid ADR - gout flare, N/V/D, headache, hypersensitivity and skin rash

Question 26

Uloric

Answer 26

Febuxostat Inhibits xanthine oxidase, preventing the conversion of hyoxanthine and xanthine to uric acid ADR - gout flare, N/V/D, headache, LFT elevations

Question 27

Krystexxa

Answer 27

Pegloticase - IV ONLY urate-oxidase enzyme which converts uric acid to allantoin DOESN'T INHIBIT FORMATION OF URIC ACID ADR - infusion reactions, gout flares, nephrolithiasis, muscle spasms, arthralgia