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Fundamentals of Molecular Medicine > Nucleic Acids > Flashcards

Flashcards in Nucleic Acids Deck (34):
1

 

 

 

Gout and Orotic Aciduria

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What is Gout?

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3

Which one of the following is not a function of a purine or pyrimidine?

Energy Source 

Precursor for Nucleic Acid Biosynthesis 

Precursor for cofactor synthesis

Second messengers 

Allosteric regulators 

Oxygen Transport 

 

 

Energy Source — ATP is an energy source

Precursor for Nucleic Acid Biosynthesis 

Precursor for cofactor synthesis— NAD

Second messengers — cAMP, AMP

Allosteric regulators — AMP

Oxygen Transport 

4

The nucleoside formed when hypoxanthine is the base is:

Zanthine

Hypoxanthosine

Adenosine

Inosine

 

 

 

Inosine

5

 

 

 

Thymine

 

 

Thiamine — comes from dUMP and N5, N10 MethylTHF

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Purine Synthesis 

2 Different Pathways

 

 

 

Dietary intake of intact Purines is Zero. They are not contributing to our salvage pathway. All dietary Purines are converted to Uric Acid

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8

The formyl carbon in N10 formyl THF cab be derived from which one of the following?

Pyruvate

Glycine 

Leucine

Lysine

Glutamate

 

 

 

Glycine — Glycine Cleavage Enzyme — Goes to N5, N10 which can go in two steps to N10 Formyl THF

9

 

 

 

Tetrahydrofolate

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10

The ribose for purine synthesis can be derived from all of the following EXCEPT for which one?

Glucose

Fructose

Lactate

Succinate

Hydroxybutarate

 

 

 

Hydroxybutarate — KB cannot be used to make sugars. All others are glycogenic.

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Synthesis of PRPP 

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12

 

 

 

Committed Step of Purine Biosynthesis

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13

Which one of the following could lead to an increase in PRPP Levels?

Type I Diabetes

Von Gierke Disease 

McArdle Disease

MCAD Deficiency

G6PDH Deficiency 

Type I Diabetes

Von Gierke Disease — G6Phosphatase deficiency— goes through HMP shunt — Gout is a symptom because of elevation G6P

McArdle Disease

MCAD Deficiency

G6PDH Deficiency — G6P doesn’t accumulate as much as G6P. 

14

 

 

 

Outline of Purine Ring Biosythesis 

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15

 

 

 

What you should know about Purine DeNovo Pathway 

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16

 

 

 

Biosynthesis of AMP from IMP

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17

 

 

 

Biosynthesis of GMP from IMP

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Conversion of AMP, GMP to more phosphorylated forms

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Regulation of DeNovo Purine Synthesis 

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20

 

 

 

Purine Synthesis and Gout

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21

 

 

 

Purine Salvage

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22

 

 

 

Purine Nucleoside Phosphorylase Deficiency 

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23

 

 

 

HGPRT Deficiency 

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24

 

 

 

Adenosine Deaminase Deficiency 

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25

 

 

 

Purine Nucleotide Cycle 

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26

What other enzyme reaction aids in buffering?

Pyruvate Dehydrogenase

Glutamine Synthetase

Glutaminase

Pyruvate Carboxylase

Alcohol dehydrogenase

Aldehyde Dehydrogenase

 

 

 

Glutaminase

27

 

 

 

Serine Derivation and Making THF

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28

 

 

 

Formate degredation can be used to make...

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29

 

 

 

Histidine Degredation can be used to make...

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30

 

 

 

Glycine can make...

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31

 

 

 

dUMP to TMP uses?

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32

 

 

 

Conversion of Glycine to Serine can be used to make...

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33

 

 

 

Homocysteine to Methionine uses...

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34

 

 

 

Purine Biosynthesis requires...

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