Nucleic Acids Flashcards Preview

Fundamentals of Molecular Medicine > Nucleic Acids > Flashcards

Flashcards in Nucleic Acids Deck (34)
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1
Q

Gout and Orotic Aciduria

A
2
Q

What is Gout?

A
3
Q

Which one of the following is not a function of a purine or pyrimidine?

Energy Source

Precursor for Nucleic Acid Biosynthesis

Precursor for cofactor synthesis

Second messengers

Allosteric regulators

Oxygen Transport

A

Energy Source — ATP is an energy source

Precursor for Nucleic Acid Biosynthesis

Precursor for cofactor synthesis— NAD

Second messengers — cAMP, AMP

Allosteric regulators — AMP

Oxygen Transport

4
Q

The nucleoside formed when hypoxanthine is the base is:

Zanthine

Hypoxanthosine

Adenosine

Inosine

A

Inosine

5
Q

Thymine

A

Thiamine — comes from dUMP and N5, N10 MethylTHF

6
Q

Purine Synthesis

2 Different Pathways

A

Dietary intake of intact Purines is Zero. They are not contributing to our salvage pathway. All dietary Purines are converted to Uric Acid

7
Q
A
8
Q

The formyl carbon in N10 formyl THF cab be derived from which one of the following?

Pyruvate

Glycine

Leucine

Lysine

Glutamate

A

Glycine — Glycine Cleavage Enzyme — Goes to N5, N10 which can go in two steps to N10 Formyl THF

9
Q

Tetrahydrofolate

A
10
Q

The ribose for purine synthesis can be derived from all of the following EXCEPT for which one?

Glucose

Fructose

Lactate

Succinate

Hydroxybutarate

A

Hydroxybutarate — KB cannot be used to make sugars. All others are glycogenic.

11
Q

Synthesis of PRPP

A
12
Q

Committed Step of Purine Biosynthesis

A
13
Q

Which one of the following could lead to an increase in PRPP Levels?

Type I Diabetes

Von Gierke Disease

McArdle Disease

MCAD Deficiency

G6PDH Deficiency

A

Type I Diabetes

Von Gierke Disease — G6Phosphatase deficiency— goes through HMP shunt — Gout is a symptom because of elevation G6P

McArdle Disease

MCAD Deficiency

G6PDH Deficiency — G6P doesn’t accumulate as much as G6P.

14
Q

Outline of Purine Ring Biosythesis

A
15
Q

What you should know about Purine DeNovo Pathway

A
16
Q

Biosynthesis of AMP from IMP

A
17
Q

Biosynthesis of GMP from IMP

A
18
Q

Conversion of AMP, GMP to more phosphorylated forms

A
19
Q

Regulation of DeNovo Purine Synthesis

A
20
Q

Purine Synthesis and Gout

A
21
Q

Purine Salvage

A
22
Q

Purine Nucleoside Phosphorylase Deficiency

A
23
Q

HGPRT Deficiency

A
24
Q

Adenosine Deaminase Deficiency

A
25
Q

Purine Nucleotide Cycle

A
26
Q

What other enzyme reaction aids in buffering?

Pyruvate Dehydrogenase

Glutamine Synthetase

Glutaminase

Pyruvate Carboxylase

Alcohol dehydrogenase

Aldehyde Dehydrogenase

A

Glutaminase

27
Q

Serine Derivation and Making THF

A
28
Q

Formate degredation can be used to make…

A
29
Q

Histidine Degredation can be used to make…

A
30
Q

Glycine can make…

A
31
Q

dUMP to TMP uses?

A
32
Q

Conversion of Glycine to Serine can be used to make…

A
33
Q

Homocysteine to Methionine uses…

A
34
Q

Purine Biosynthesis requires…

A

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