Nucleotides Flashcards Preview

Biochemistry > Nucleotides > Flashcards

Flashcards in Nucleotides Deck (36):
1

Monomer units or building blocks of nucleic aids

Nucleotides

2

Sugar+ Purine or Pyrimidine

NucleoSIDE

3

Bond in nucleosides

B-N-glycosidic bond

4

Nucleosides with a phosphoryl group esterified to a hydroxyl group of the sugar

NucleoTIDES

5

Most nucleotides have a phosphoryl group attached to what Carbon?

Carbon 5 (5'-nucleotides)

6

Catalyze the hydrolysis of phosphodiester bonds

Phosphodiesterases

7

Sources of atoms in purine synthesis

Aspartic acid, Glycine, Glutamine, CO2, N10-formyltetrahydrofolate and N5, N10 methenyltetrahydrofolate

8

Sources of atoms in pyrimidine synthesis

Glutamine, aspartic acid, carbon dioxide

9

Nucleotide not found in DNA

Uracil

10

Nucleotide not found in RNA

Thymine

11

Bond that holds 2 nucleotides together

Phosphodiester bond

12

Sources of atoms for both purine and pyrimidine

Glutamine, aspartic acid

13

Atoms source exclusively for purine synthesis

Glycine, N10-formyltetrahydrofolate, and N5N10 methenyltetrahydrofolate

14

Enzyme for PRPP syntesis

PRPP synthase

15

Enzyme for 5'-phosphoribosylamine

Glutamyl PRPP amidotransferase

16

Committed step in purine nucleotide biosynthesis

5'-phosphoribosylamine

17

Base of inosine monophosphate

Hypoxanthine

18

Parent purine nucleotide

Inosine monophosphaye

19

AMP synthesis requires what molecule?

GTP

20

GMP synthesis requires what molecule?

ATP

21

Source of ribose 5'-P

PRPP

22

Irreversible Enzymes

APRT, HGPRT

23

Regulated and rate limiting step in pyrimidine synthesis

Synthesis of Carbamoyl phosphate

24

Parent pyrimidine nucleotide

Orotidine monophosphate

25

OMP is converted to UMP by what enzyme

OMP decarboxylase

26

Enzyme in synthesis of dTMP from dUMP

Thymiylate synthase

27

Salvageable pyrimidines

Uridine,cytidine, deoxycytidine, thymidine

28

Enzyme necessary for synthesis of deoxyribonucleotides

Ribonucleotide reductase

29

Regeneratea the reduced form of ribonucleotide reductase

Thioredoxin

30

Dietary purines are generally converted to?

Uric acid

31

Precursor for uric acid?

Xanthine

32

Responsible for xanthine to uric acid rxn

Xanthine oxidase

33

Products of pyrimidine degredation

B-alanine,B- aminoisobutyrate

34

Succinyl coA precursor

B- aminoisobutyrate

35

Acetyl CoA precursor

B-alanine

36

Structural analogs of PABA that competitively inhibit bacterial synthesis of folic acid

Sulfonamides