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Flashcards in Nutrition and Cardiovascular Disease Deck (27)
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1

What are the major changeable risk factors for CVD?

High blood cholesterol, smoking, hypertension

2

What are the other risk factors for CVD?

1. Genetics
2. Male -> although females have higher rate after menopause
3. Age
4. Race
5. Diabetes
6. Low HDL, High TG
7. Inactivity
8. Personality, including stress and coping tendencies

3

How do CVD risk factors work together?

Synergistically

4

Which apoproteins are considered atherogenic and what are they found on?

Apo B-100: LDL, IDL, VLDL
Apo E: IDL, VLDL only

5

Which apoproteins are associated with lower risk for CVD and what are they found in?

All Apo-A

A-1, A-4 = Chylomicrons
A-1, A-2 = HDL

6

What are the two subclasses of LDL particles and which one is considered more atherogenic? Why?

Phenotype A: Lower risk -> large
Phenotype B: Higher risk -> smaller

Smaller particles more easily infiltrate the endothelium

7

What diseases does high wait circumference increase risk for?

CVD, Type 2 diabetes, gall bladder disease

8

What are the best sources of MUFA's (good)?

Olive oil > Canola oil > Peanut oil

9

What are the best sources of PUFA's (good)?

Safflower oil, sunflower oil, corn oil, soybean oil, all n-6, although fish n-3 is the best

10

What are the best sources of SF's (bad)?

Coconut oil, palm kernel oil, butter, animal fats

11

Which oil is thought to be beneficial even though it is high in saturated fat and why?

Palm oil - probably because it is high in vitamin E. It has a positive effect on blood cholesterol levels.

12

What are the positive effects of MUFA's?

1. Lower LDL while not lowering HDL
2. Improve resistance to LDL oxidation
3. Reduce macrophage uptake of o-LDL as compared to saturated fatty acids or carbohydrates

13

What is the effect of trans fat?

Atherogenic, raises level of small, dense LDL cholesterol + systemic inflamation

14

What is the significance of conjugated linoleic acid?

It is an n-6 PUFA which is a naturally-occurring trans-fat, actually has anticarcinogenic activity

15

What is alpha-Linolenic acid (ALA) and what is the current recommendation?

It is an n-3 PUFA which comes from walnuts, canola oil, flaxseed oil, and is converted to EPA and DHA (two important eicosanoids), very gud for you

16

Why are fish n-3 PUFA's better than plant n-3 PUFA's?

Fish n-3's are already EPA and DHA, plant n-3's like ALA must be converted in the body into EPA and DHA. This is done much more readily in females

17

What are the positive effects of n-3 PUFA?

Reduce thromboxanes, which aggregate platelets

Lower arachidonic acid synthesis as well as enzymes which convert it to inflammatory leukotrienes.

improving hemodynamics by reducing blood viscosity, blood pressure, and TAG levels.

Reduce number of small size LDL particles, and counteract vessel proliferation and atherogenic lesion site.

18

What is the primary n3 eicosanoid and its effect?

Prostacyclin - vessel dilation, lower platelet aggregation

19

What is primary n6 eicosanoid and its effect?

Thromboxane - platelet aggregation and vasoconstriction

20

Are saturated fats bad? What's most important?

Likely neutral. What's most important is what those calories are replaced by -> low quality carbohydrates are worse. Carbohydrates increase CVD risk by lowering HDL and increasing TAGs

21

What is the order of the best fatty acids for protecting against CVD?

Fish n3 > plant n3 > plant n6 > MUFA > saturated fats

22

What are the 9 risk variables for CVD risk assessment?

1. Sex
2. Age
3. Race
4. Smoker (yes/no)
5. Total cholesterol
6. HDL cholesterol
7. Systolic blood pressure
8. Treatment for hypertension (yes/no)
9. Diabetes (yes/no)

23

What are the components of the DASH diet?

Dietary Approaches to Stop Hypertension
1. High fruits / vegetables
2. High in diary
3. High in K, Ca, Mg as a result
4. Low in sodium reduces blood pressure

24

Who is the DASH diet best for?

Hypertensives, African-Americans

25

What are the typical nutritional problems that arise after a stroke?

1. Dysphagia - difficulty swallowing. May include choking / dehydration and lead to temporary or permanent weight loss
2. Physical disability - unable to feed oneself, but also lack of physical activity can cause weight gain

26

What percentage of cardiovascular accident (CVA) / stroke patients have malnutrition, and what is the recommendation for these patients?

Up to 50%. Ischemic CVA who are nutritionally compromised on admission are more likely to become malnourished and have worse outcomes.

Recommendation: Give 240 additional calories + 11g of protein, gives much better outcomes

27

What are the two types of stroke?

Ischemic and hemorrhagic. Ischemic makes up 80%