Flashcards in Occupational Lung Diseases/Exposures Deck (23):
True or False: the clinical and pathologic expressions of occupational lung diseases is indistinguishable from those of non-occupational diseases
True. So you really have to use occupational history to find out.
With occupational lung diseases is often a ____ between the onset of exposure and first expression of disease.
It is important to consider exposure ____ when thinking about occupational lung diseases
What are the 3 major determinants of site and severity of occupational lung disease? *know this slide well*
1. Dose (dose = duration x concentration)
2. Solubility (more water soluble agents deposit in the upper airway and less water soluble agents deposit in the distal airways/bronchioles)
3. Particle size (greater than 10 microns are filtered in the upper airway while less than 10 microns penetrate more deeply into the lung. less than 2.5 microns may affect small airways and alveoli.)
What questions should you ask when evaluating for occupational lung disease/exposure?
Where do you work?
What job titles have you had?
What were your specific job duties?
Use of PPE?
Similar symptoms in coworkers?
Description of work place and processes?
What are the 2 general categories of occupational lung disease?
Airway disease and interstitial disease
Name the 4 occupational airway diseases
1. Immunologic asthma (asthma w latency) - isocyanates*
2. Irritant asthma (RADS) - chemical spill*
3. Emphysema/COPD (coal mine dust/silica*)
4. Bronchiolitis (obliterative/constrictive)
What is pneumoconiosis? (3)
Dust related lung disease
Asbestos-related lung disease
Coal miners pneumoconiosis
When an adult without history of asthma gets asthma, what should you think?
Occupational and environmental causes.
What are isocyanates?
Spray paint, auto body repair
What is the big difference between occupational asthma and irritant asthma (RADS)? *know this one*
Onset of occupational asthma may be months to years after the exposure. There is a temporal pattern in the symptoms of SOB and wheezing on weekends and holidays.
RADS doesn't have latency period. It expresses symptoms immediately or within 24-48 hours.
True or False: exposure to isocyanates that causes asthma can be respiratory or dermal
What is RADS?
Reactive airway dysfunction syndrome
Airway epithelial injury from exposure to inhalants with irritant properties, leading to persistent hyper responsiveness and airflow obstruction. This can be caused by noxious irritant gas/vapors/dusts (e.g. WTC works exposed to high pH alkaline dust), chlorine exposure
What is the most common cause of COPD and emphysema occupationally?
Silica. Lung can't clear.
If you hear "pleural plaques" what should you think?
Silicosis has a ____ latency period
Coal Workers pneumoconiosis has ___ latency period
Coal Worker Pneumoconiosis
Think birds, animal dander, farmers
Why not asking about presentation?
Bc they are all similar. The key to this lecture is concentrating on occupational and environmental history.
Causes of silica
Mining, sand blasting, foundry work