October 5, 2015 - SG - Neutropenia & Immune Function Flashcards Preview

COURSE 1 > October 5, 2015 - SG - Neutropenia & Immune Function > Flashcards

Flashcards in October 5, 2015 - SG - Neutropenia & Immune Function Deck (11):
1

Piperacillin / Tazobactam

Some heavy duty antibiotics. Must be administered IV.

Piperacillin is a extended-spectrum penicillin, and tazobactam is a B-lactamase inhibitor.

The combination has activity against many Gram-positive and Gram-negative pathogens, as well as Pseudomonas aeruginosa.

2

Ciprofloxacin

Gram negative coverage.

DNA inhibitor.

3

VINDICATE

Vascular

Infection

Neoplasm/infiltrate

Drug

Inflammation

Congenital

Autoimmune

Trauma

Endocrine

4

Play Table Tennis

Play table tennis INSIDE

Therefore INTRINSIC pathway

5

Play Tennis

Play tennis OUTSIDE

Therefore EXTRINSIC pathway

6

Elevated INR/PTT with Infection

May indicate DIC.

Tissue factor is released into the blood and causes clots to form everywhere. This uses up everything (platelets and factors) and causes oozing.

7

Auer Rods

Red staining, needle-like bodies that can be seen in the cytoplasm of myeloblasts in certain leukemias, particular AML.

A image thumb
8

Bone Marrow Biopsy and Leukemia

A bone marrow biopsy must be performed. This will differentiate between AML and ALL, as well as determine the cytogenetics of the particular cancer. This is done by flow cytometry and is imperitive as it has big indications on which treatment the patient is going to receive and their likely prognosis.

9

AML vs ALL

AML

More common in adults

Auer rods

ALL

More common in children

Often has bony pain

10

Common Variable Immunodeficiency (CVID)

Is the most commonly diagnosed primary immunodeficiency. It is characterized by low antibody levels and recurrent infections.

Main features are hypogammoglobinemia, as well as often hypoalphaglobinemia. Most frequently, the bacteria that cause infection are Haemophilus infleizae, Streptococcus pneumoniae, and Staphylococcus aureas (encapsulated organisms).

Treatment is usually IVIG, SCIG, or IMIG.

11

Treatment of CVID

IVIG / SCIG / IMIG

Prophylactic antibiotics

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