Omeprazole Flashcards
1
Q
What class of drug is omeprazole?
A
Proton pump inhibitor
2
Q
What are the uses of omeprazole?
A
- H. Pylori eradication
- PUD
- protection alongside NSAIDs
- GORD
3
Q
What is the mechanism of action of omeprazole?
A
Irreversible inhibit H+/K+ ATPase in gastric parietal cells > reduces stomach acid secretion
4
Q
What are adverse drug reactions for omeprazole?
A
- Abdominal pain
- constipation/diarrhoea
- headache + dizziness
- confusion
- can mask symptoms of gastro-oesophageal cancer
5
Q
What are important drug drug interactions of omeprazole?
A
- Omeprazole is a CYP inhibitor > reduces clopidogrel action
- can increase effects of warfarin + phenytoin
6
Q
How could PPI be prescribed?
A
Shortest effective duration at lowest effective dose
