Oncogenes & Tumor Suppressor Genes Flashcards Preview

Step One!!!! Kat's kontributions > Oncogenes & Tumor Suppressor Genes > Flashcards

Flashcards in Oncogenes & Tumor Suppressor Genes Deck (21):
1

abl

Oncogene
Associated w/ CML
Gene product: Tyrosine kinase

2

c-myc

Oncogene
Associated w/ Burkitt's lymphoma
Gene product: Transcription factor

3

bcl-2

Oncogene
Associated w/ Follicular & undifferentiated lymphomas (inhibits apoptosis)
Gene product: Anti-apoptotic molecule

4

erb-B2

Oncogene
Associated w/ breast, ovarian, & gastric carcinomas
Gene product: Tyrosine kindase

5

ras

Oncogene
Associated w/ colon carcinoma, pancreatic adenocarcinoma
Gene product: GTPase

6

L-myc

Oncogene
Associated w/ Lung tumor
Gene product: Transcription factor

7

N-myc

Oncogene
Associated w/ neuroblastoma
Gene product: Transcription factor

8

ret

Oncogene
Associated w/ MEN IIA & MEN IIB
Gene product: Tyrosine kinase

9

c-kit

Oncogene
Associated w/ GI stromal tumor
Gene product: Cytokine receptor

10

Rb

Tumor Suppressor Gene
Associated w/ retinoblastoma, osteosarcoma
Gene product: Rb gene product blocks G1 --> S phase of the cell cycle

11

p53

Tumor Suppressor Gene
Associated w/ most human cancers, especially Li-Fraumeni syndrome
Gene product: p53 product blocks G1 --> S phase of the cell cycle

12

BRCA1

Tumor Suppressor Gene
Associated w/ breast & ovarian cancer
Gene product: DNA repair protein

13

BRCA2

Tumor Suppressor Gene
Associated w/ breast cancer
Gene product: DNA repair protein

14

p16

Tumor Suppressor Gene
Associated w/ melanoma

15

APC

Tumor Suppressor Gene
Associated w/ colorectal cancer (associated w/ FAP)

16

WT1

Tumor Suppressor Gene
Associated w/ Wilms' tumor

17

NF1

Tumor Suppressor Gene
Associated w/ Neurofibromatosis Type I

18

NF2

Tumor Suppressor Gene
Associated w/ Neurofibromatosis Type II

19

DPC

Tumor Suppressor Gene
Associated w/ Pancreatic cancer

20

DCC

Tumor Suppressor Gene
Associated w/ colon cancer

21

VHL

Tumor Suppressor Gene
Associated w/ Renal Cell Carcinoma, VHL Syndrome
Gene product: Ubiquitin ligase component