Flashcards in One Carbon Deck (27):
What C1 source does Biotin carry?
What C1 source does SAM carry?
What C1 source does FH4 carry?
TRP, SER, GLY
What reactions use biotin?
What reactions use SAM?
What reactions use FH4?
Purine, Pyramidine Synth.
Main Biotin Enzymes?
Pyruvate Carboxylase, Acetyl CoA Carboxylase, Propionyl CoA Carboxylase
Enzyme for adding Biotin in?
What pulls biotin off a used enzyme?
Holocarboxylase synthetase deficiency?
No holo.... Bald and encephaly
________ methylates ________ methylates Homocysteine to make ________
FH4-CH3. B12-CH3. Methionine.
What enzyme makes SAM --> SAH
Tetrahydrofolate come from which B vitamin
Enzyme that makes FH4?
In FH4, what binds N5?
In FH4, what binds N10?
In FH4, what binds N5/10?
-CH= and -CH2-
In B9 deficiency, what happens?
Neural Tube defects, DNA replication problems
Cause of B9 deficiency?
Drug to lower FH4?
Methotrexate (Folic Acid Analog)
What is B12 there for?
Homo --> Meth and Methylmalonyl CoA --> Succ. CoA
B12 deficiency will ______ homocysteine and ________ FH4.
B12 deficiency symptoms?
Megaloblastic Anemia. Neurological Deterioration. Decreased BCAA degradation. Hyperhomocystenemia.
What is hyperhomocysteinemia?
To much homo in the blood, increased risk of coronary, stroke. Caused by lowered Folate/B12 or fucked up cystathione beta synthase.
Alternate pathway for Homo--> Met? Who can't do it?
Causes of B12 deficiency?
Vegan diet, pernicious anemia, malabsorption