One Carbon Flashcards Preview

Bryochemistry Last Exam > One Carbon > Flashcards

Flashcards in One Carbon Deck (27):
1

What C1 source does Biotin carry?

CO2

2

What C1 source does SAM carry?

MET

3

What C1 source does FH4 carry?

TRP, SER, GLY

4

What reactions use biotin?

Carboxylations

5

What reactions use SAM?

Methylations

6

What reactions use FH4?

Purine, Pyramidine Synth.

7

Main Biotin Enzymes?

Pyruvate Carboxylase, Acetyl CoA Carboxylase, Propionyl CoA Carboxylase

8

Enzyme for adding Biotin in?

Holocarboxylase Synthatase

9

What pulls biotin off a used enzyme?

Biotinidase

10

Holocarboxylase synthetase deficiency?

No holo.... Bald and encephaly

11

________ methylates ________ methylates Homocysteine to make ________

FH4-CH3. B12-CH3. Methionine.

12

What enzyme makes SAM --> SAH

Methyl Transferase

13

Tetrahydrofolate come from which B vitamin

9 (Folate)

14

Enzyme that makes FH4?

Dihydrofolate reductase

15

In FH4, what binds N5?

CH3

16

In FH4, what binds N10?

CHO

17

In FH4, what binds N5/10?

-CH= and -CH2-

18

In B9 deficiency, what happens?

Neural Tube defects, DNA replication problems

19

Cause of B9 deficiency?

Probs Alcoholism

20

Drug to lower FH4?

Methotrexate (Folic Acid Analog)

21

What is B12 there for?

Homo --> Meth and Methylmalonyl CoA --> Succ. CoA

22

B12 deficiency will ______ homocysteine and ________ FH4.

Increase. Decrease.

23

B12 deficiency symptoms?

Megaloblastic Anemia. Neurological Deterioration. Decreased BCAA degradation. Hyperhomocystenemia.

24

What is hyperhomocysteinemia?

To much homo in the blood, increased risk of coronary, stroke. Caused by lowered Folate/B12 or fucked up cystathione beta synthase.

25

Alternate pathway for Homo--> Met? Who can't do it?

Betamine. Brain

26

Causes of B12 deficiency?

Vegan diet, pernicious anemia, malabsorption

27

What happens in macrocytic anemia?

Inhibition of DNA synthesis, while RNA synthesis goes on leads to abnormally large/irregular cells.