Opioid Analgesics and Antagonists Flashcards Preview

P Pha T > Opioid Analgesics and Antagonists > Flashcards

Flashcards in Opioid Analgesics and Antagonists Deck (12):
1

Opioid with shortest half-life ?
Longest half-life?

Remifentanil
Buprenorphine

2

OPIOID RECEPTORS
Mu - inhibition of ___________
Delta - development of __________
Kappa - ________ gastrointestinal transit

OPIOID RECEPTORS
Mu - inhibition of respiration
Delta - development of tolerance
Kappa - slowed gastrointestinal transit

Think
Mu - Mabagal hUminga
DelTa - Tolerance
Kappa - Konstipation

3

Most potent opioid

Ohmefentanyl

4

Opioid of choice for pain relief in pancreatitis

Meperidine

5

Full agonist
Exerts hemodynamics effects on the pulmonary circulation

Morphine

6

Morphine, meperidine, methadone, fentanyl
A. Strong/full agonist
B. Moderate/partial agonist
C. Weak agonist

Strong (M + fentanyl)

7

Codeine, oxycodone, hydrocodone, dextrometorphan
A. Strong/full agonist
B. Moderate/partial agonist
C. Weak agonist

Moderate/partial (C + dextrometorphan)

8

Weak opioid agonist
Commonly used in suicides

Propoxyphene

9

Buprenorphine, nalbuphine, butarphonol, pentazocine
A. Strong/full opioid agonist
B. Moderate/partial agonist
C. Weak agonist
D. Mixed agonist-antagonist
E. Antagonist
F. Dual-acting

Mixed (bu + pentazocine)

10

Naloxone
Buprenorphine, nalbuphine, butarphonol, pentazocine
A. Strong/full opioid agonist
B. Moderate/partial agonist
C. Weak agonist
D. Mixed agonist-antagonist
E. Antagonist
F. Dual-acting

Antagonist

11

Dual-acting:
Weak agonist at mu receptors; inhibits neuronal reuptake of serotonin and norepinephrine;
Inhibits pain neurotransmission

Tramadol

12

Triad of Opioid overdose

PCR
Pupillary constriction
Comatose state
Respiratory depression

Decks in P Pha T Class (62):