Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc Flashcards Preview

Pharm 512 Drugs > Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc > Flashcards

Flashcards in Opioid, Opioid agonist/antagonist, antagonist dosing, MOA, etc Deck (37):
1

What type of drug is Fentanyl?

Opioid Agonist, phenylpiperidine

2

What type of drug is Meperidine (Demerol)?

It is a opioid analgesic. A phenylpiperdine

3

What is the half-life for Morphine?

2-3 hr

4

What type of Drug is Sufentanil?

Opioid Agonist, phenylpiperidine

5

What is the half-life of Meperidine?

3-5 hr

7

What is the narcotic equivalent for Morphine?

1 , it is what we compare everything to.

8

What is the Narcotic equivalent for Meperidine?

1/10, or 0.1

9

What are the side-effects/contraindications for Fentanyl?

Asthenia, confusion, dry mouth, constipation, N/V

10

What type of drug is Morphine?

Opioid Agonist, phenanthrene

11

What type of drug is Alfentanil?

Opioid Agonist, phenylpiperidine

12

What is the dose of Meperidine?

2.5-5 mg/kg

12

What is the volume of distribution for Morphine?

3-5 L/Kg

14

What is the half-life of Fentanyl?

1-5 hr
CS (context sensitive):
4 hours

15

What is the MOA of Meperidine (Demerol) and how is it metabolized and eliminated?

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal

16

What is the MOA, metabolism, and excretion of Sufentanil?

Opioid receptor agonist
Metabolism: Liver
Elimination: Renal, biliary

17

What are the side effects/contraindications of Meperidine?

Histamine release, N/V, constipation, hypotension, anti-shivering-kappa

17

What is the induction dose of Fentanyl?

Induction: 1-2 mcg/kg then 1-3 mcg/kg/hr continuous

18

What are the side effects/contraindications of Sufentanil?

Asthenia, confusion, constipation, N/V, dry mouth

20

What are the loading and maintenance doses of Alfentanil?

Loading: 8-100 mcg/kg
Maintenance: 0.5-3 mcg/kg/min

21

What is the induction dose for Sufentanil?

Induction: 1-2 mcg/kg then 10-50 mcg prn; Anesthesia: 8-30 mcg then 25-30 mcg prn

22

What is the MOA, metabolism and excretion of Fentanyl?

Opioid receptor agonist
Metabolism: Lung and Liver (dependent on blood flow)

23

Naloxone: MOA, dose, ½ life, route of metabolism and elimination

Opioid antagonist
Competitive antagonism of opiate receptors
Metabolism: Liver
Elimination: Renal
Dose (incremental) 0.4 mg (10 mcg/kg) may repeat q2-3 min
1/2 life: 60-90 min
Side effects/contraindications: Withdrawal reactions (N/V, tachycardia, sweating, HTN, tremors), cardiac arrest, VF, pulm edema

24

What are the side effects/contraindications for Morphine?

Histamine release, pruritis, vomiting, urinary retention, constipation, HA

25

What is Fentanyl's Vd?

2-8

25

What is the half-life of Sufentanil?

3 hr
CS (context sensitive):
30 min

26

What is the half-life of Alfentanil?

1-2 hr
CS:
60 min.

27

What is the narcotic equivalent of Sufentanil?

500-1000

30


Nalbuphine (Nubain): MOA?

Opioid Agonist/ antagonist
Opiate receptor agonist in CNS

31

What is the MOA, metabolism, and excretion of Alfentanil?

Opioid receptor agonist
Metabolism: Liver
Excretion: Renal

32

What is Meperidine's volume of distribution?

3-5 L/Kg

32

What is the narcotic equivalent for Fentanyl?

100

33

What is the Vd of Sufentanil?

2.5-3 L/Kg

33

What is the narcotic equivalent of Alfentanil?

10-20

34

Remifentanil: Class, MOA, induction dose, Vd, 1/2 life, metabolism, excretion

Opioid Agonist, phenylpiperidine
Opioid receptor agonist
Metabolism: Non-specific esterases
Excretion: Metabolites are renally excreted
Loading: 1 mcg/kg
Intra-op: 0.5-3mcg/kg/min
Narc equivalent 100
Vd: 0.3-0.4L/Kg
Half life: <10min CS: 4 min.
Side effects: Asthenia, confusion, constipation, N/V, dry mouth

35

What is Morphine's MOA, metabolism, and excretion?

Opioid receptor agonist
Metabolism: Liver
Excretion: Renal

35

Butorphanol (Stadol): Class and MOA?

Opioid Agonist/ antagonist
Opiate receptor agonist in CNS


36

What are the side effects/contraindications of Alfentanil?

Asthenia, confusion, constipation, N/V, dry mouth