Opioid toxicity Flashcards
T or F: We tx natural, semi-synthetic, and synthetic toxicities differently.
F
Absorption of opioids is dependent on what?
- specific opioid
2. route of admin
In opioid toxicity, tmax following oral administration may _____.
increase
T or F: Opioid distribution and metabolism is quite variable across different opioids and different inds
T
t1/2 for most opioids?
2-10h
Methadone t1/2?
8-59h
T or F: It’s important to determine WHICH opioid a pt is overdosing on upon presentation.
F
It’s more important to know that it’s an opioid that’s causing toxicity, but it’s not as important to know which one
Main sx’s assoc w/ opioid toxicity?
- resp depression
- CNS depression
- miosis (pinpoint pupils)
What is the worst outcome of opioid-induced CNS depression?
Coma
What is the most likely cause of hypotn in opioid toxicity?
Histamine release
Which opioid is most likely to cause QT prolongation?
methadone
Which opioid is most likely to cause tachycardia and HTN?
tramadol
GI sx’s assoc w/ opioid toxicity?
N/V, constipation/reduced bowel sounds
What movement disorder can occur due to opioids?
Muscular rigidity of the trunk > hypoventilation (diaphragm activity is reduced)
Skin side effect(s) of opioid toxicity? What causes it/them?
itchiness > histamine causes it
