opioids Flashcards Preview

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Flashcards in opioids Deck (20):
1

morphine

-full mû agonist
-long acting

2

methadone

-full mû agonist
-much longer acting than morphine
-better oral absorption
-can produce QT-interval prolongation in acute overdose or during long term treatment, this is unrelated to mu receptors

3

meperidine

-full mû agonist
-long acting
-cause pupil DIALATION
-produces toxic metabolite, normeperidine = seizures

4

hydromorphone

-full mû agonist
-long acting

5

oxymorphone

-full mû agonist
-long acting

6

levorphanol

-full mû agonist
-long acting

7

fentanyl

-full mû agonist
-short acting
-100x more potent than morphine
-respiratory depression

8

sufentanil

-full mû agonist
-short acting
-100x more potent than morphine
-acts at mu, k, delta receptors

9

remifentanil

-full mû agonist
-VERY short acting
-100x more potent than morphine
-popular for providing analgesia for childbirth, rapidly metabolized by fetus lowering risks of respiratory depression

10

hydrocodone

-codeine related
-partial agonist at mû receptors
-analgesia for moderate pain
-cough relief, not by mû receptor

11

oxycodon

-codeine related
-partial agonist at mû receptors
-analgesia for moderate pain
-cough relief, not by mû receptor

12

dextromethophan

-relieves cough independently of opioid receptors
-not analgesic, not addictive

13

loperamide

-anti-diarrheal
-interact with mu receptor in gut

14

diphenoxylate

-anti-diarrheal
-interact with mu receptor in gut

15

tramadol

-moderate mu agonist
-reliable oral absorption
-analgesia for moderate pain
-inhibits catecholamine reuptake
-can cause seizures

16

pentazocine

-k agonist + mu partial agonist + delta antagonist
-supra spinal analgesia
-can precipitate withdrawal
-tachycardia, hallucination

17

buprenorphine

-mu partial agonist + k/delta antagonist
-detox/maintance with naloxone

18

naloxone

-mu antagonist
-treats opioid overdose
-IV only
-short duration - watch for relapse overdose

19

naltrexone

-mu antagonist
-treats opioid overdose
-oral only
-long duration

20

methylnaltrexone

-quaternary derivative of naltrexone
-restricted ability to cross blood-brain barrier
-opioid antagonist
-inhibits opioid induced constipation
-does not affect analgesic effects