Oral Hypoglycemics Flashcards Preview

Pharmacology > Oral Hypoglycemics > Flashcards

Flashcards in Oral Hypoglycemics Deck (23):
1

Chlorpropamide (Diabenese)

First gen sulfonylureas

-Stimulates insulin secretion
-Reduces glucose output from liver by decrease glycogenolysis
-Increases insulin sensitivity in cells

2

Tolbutamide (Orinase)

First gen sulfonylureas

-Stimulates insulin secretion
-Reduces glucose output from liver by decrease glycogenolysis
-Increases insulin sensitivity in cells

3

Glyburide (DiaBeta, Micronase)

Second gen sulfonylureas

-Stimulates insulin secretion
-Reduces glucose output from liver by decrease glycogenolysis
-Increases insulin sensitivity in cells

4

Glipizide (Glucotrol)

Second gen sulfonylureas

-Stimulates insulin secretion
-Reduces glucose output from liver by decrease glycogenolysis
-Increases insulin sensitivity in cells

5

Sulfonylureas*

*Sulfa allergies, thiazide diuretic, renal/hepatic disease

6

Metformin (Glucophage, Glumetza)

Biguanides*

-v hepatic glucose production, intestional glucose absorption, increases tissue sensitivity to insulin
*Lactic acidosis, renal insufficiency, CHF, alcoholics
**Cimetidine (Tagamet), digoxin (Lanoxin), vancomycin (^ concentration due to renal tubular secretion competition)/herbals (hypoglycemia)

7

Repaglinide (Prandin)

Meglitinides

-Stimulate insulin secretion (quick insulin burst - 20 min)
-Good for renal patients

8

Nateglinide (Starlix)

Meglitinides

-Stimulate insulin secretion (quick insulin burst - 20 min)
-Good for renal patients

9

Acarbose (Precose)

Alpha-glucosidase inhibitors

-Delayed absorption of carbs by inhibiting glucosidase in small intestine

10

Miglitol (Glyset)

Alpha-glucosidase inhibitors

-Delayed absorption of carbs by inhibiting glucosidase in small intestine

11

Biguanides*

*Lactic acidosis, renal insufficiency, CHF, alcoholics
**Cimetidine (Tagamet), digoxin (Lanoxin), vancomycin (^ concentration due to renal tubular secretion competition)/herbals (hypoglycemia)

12

Alpha-glucosidase inhibitors*

<18 years, hiatal hernias, digestive disease

13

Rosiglitazone (Avandia)

Thiazolidinediones

-Reduces insulin resistance, inhibit hepatic gluconeogensis

14

Pioglitazone (Actos)

Thiazolidinediones

-Reduces insulin resistance, inhibit hepatic gluconeogensis

15

Thiazolidinediones*

Hepatic pts, CHF, decrease level of oral contraceptives

16

Sitagliptin (Januvia)*

Dipeptide Peptidase-4 Inhibitor (DP-4)*

-Inhibits DP4, protects incretin hormones, reduces hepatic glucose production

*Digoxin, sulfonylureas (to prevent hypoglycemia)

17

Vildagliptin (Galvus)

Dipeptide Peptidase-4 Inhibitor (DP-4)

-Inhibits DP4, protects incretin hormones, reduces hepatic glucose production

18

Exenatide (Byetta)

GLP-1 Agonists

-Synthetic incretin mimetic, decreases blood glucose levels

19

Exenalide (Bydureon)

GLP-1 Agonists

-Synthetic incretin mimetic, decreases blood glucose levels

20

Liraglutide (Victoza)

GLP-1 Agonists

-Synthetic incretin mimetic, decreases blood glucose levels

21

Pramlintide (Symlin)

Amylin Analogue

-Slows gastric emptying, postprandial glucose metabolism, use with insulin

22

Canagliflozin (Invokana)

SGLT-2 Inhibitor

-Blocks kidney rebasorption of glucose

23

Farxiga (Dapagliflozin)

SGLT-2 Inhibitor

-Blocks kidney rebasorption of glucose