ORGANOTROPIC AGENTS - Drugs for Angina Pectoris treatment Flashcards Preview

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Flashcards in ORGANOTROPIC AGENTS - Drugs for Angina Pectoris treatment Deck (48):
1

Angina pectoris is

Severe constricting chest pain, often radiating from the precordium to the left shoulder and down the arm, due to insufficient blood supply to the heart that is usually caused by coronary disease

2

These drug groups useful in angina both decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)

- Nitrates and nitrite drugs (Nitroglycerin, Isosorbide dinitrate)
- Calcium channel blockers (Nifedipine, Nimodipine)
- Potassium channel openers (Minoxidil)

3

This drug group useful in angina decreases myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and does not increase myocardial oxygen delivery (by reversing coronary arterial spasm)

Beta-adrenoceptor-blocking drugs (Atenolol, Mtoprolol)

4

This drug group useful in angina increase myocardial oxygen delivery (by reversing coronary arterial spasm) and does not decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand)

Myotropic coronary dilators (Dipyridamole)

5

True or False about nitrate mechanism of action. Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in to vascular smooth muscle
target tissues.

TRUE

6

True or False about nitrate mechanism of action. Nitric oxide (NO) is an effective activator of soluble guanylyl cyclase and probably acts mainly through this mechanism

TRUE

7

True or False about nitrate mechanism of action. Nitrates useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)

TRUE

8

Which nitrates and nitrite drugs are long-acting?

Sustac

9

Which nitrates and nitrite drugs is a short-acting drug?

Amyl nitrite, inhalant (Aspirols, Vaporole)

10

Which nitrates and nitrite drugs is used for prevention of angina attack?

- Nitroglycerin, 2% ointment (Nitrol)
- Nitroglycerin, oral sustained-release (Nitrong)
- Isosorbide mononitrate (Ismo)

11

Duration of nitroglycerin action (sublingual) is

10-30 minutes

12

True or False about the mechanism of nitrate beneficial clinical effect. Decreased myocardial oxygen requirement

TRUE

13

True or False about the mechanism of nitrate beneficial clinical effect. Relief of coronary artery spasm

TRUE

14

True or False about the mechanism of nitrate beneficial clinical effect. Improved perfusion to ischemic myocardium

TRUE

15

True or False about the mechanism of nitrate beneficial clinical effect. Increased myocardial oxygen consumption

FALSE

16

Side effect of nitrates and nitrite drugs are

- Orthostatic hypotension, tachycardia
- Throbbing headache
- Tolerance

17

True or False about mechanism of calcium channel blockers’ action. Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in vascular smooth muscle target tissues

FALSE

18

True or False about mechanism of calcium channel blockers’ action. Calcium channel blockers bind to L-type calcium channel sites

TRUE

19

True or False about mechanism of calcium channel blockers’ action. Calcium channel blockers useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)

TRUE

20

True or False about mechanism of calcium channel blockers’ action. Calcium channel blockers decrease transmembrane calcium current associated in smooth muscle with long-lasting relaxation and in a cardiac muscle with a reduction in contractility

TRUE

21

Which antianginal agents is a calcium channel blocker?

Nifedipine

22

Which cardiovascular system effects refers to a calcium channel blocker?

- The reduction of peripheral vascular resistance
- The reduction of cardiac contractility and, in some cases, cardiac output
- Relief of coronary artery spasm

23

Main clinical use of calcium channel blockers is

- Angina pectoris
- Hypertension
- Supraventricular tachyarrhythmias

24

Which antianginal agents is a myotropic coronary dilator

Dipyridamole

25

Which antianginal agents is a beta-adrenoceptor-blocking drug

Atenolol

26

The following agents are cardioselective beta1-adrenoceptor-blocking drugs labeled for use in angina

- Metoprolol
- Talinolol
- Atenolol

27

The following agents are not cardioselective beta1-adrenoceptor-blocking drugs labeled for use in angina

Propranolol

28

True or False about beta-adrenoceptor-blocking drugs. These agents decrease transmembrane calcium current associated in a smooth muscle with long-lasting relaxation and in a cardiac muscle with a reduction in contractility

TRUE

29

True or False about beta-adrenoceptor-blocking drugs. These agents has a moderate reflex and vascular dilative action caused by the stimulation of sensitive nerve endings

TRUE

30

True or False about beta-adrenoceptor-blocking drugs. Beneficial effects of these agents are related primarily to their hemodynamic effects – decreased heart rate, blood pressure, and contractility – which decrease myocardial oxygen requirements at rest and during exercise

FALSE

31

True or False about beta-adrenoceptor-blocking drugs. These agents increase the permeability of K channels, probably ATP-dependent K channels, that results in stabilizing the membrane potential of excitable cells near the resting potential

TRUE

32

Which antianginal agents refers to reflex coronary dilators:

Validol

33

True or False about Validol. Validol has a moderate reflex and vascular dilative action caused by the stimulation of sensitive nerve endings

TRUE

34

True or False about Validol. At sublingual administration the effect is produced in five minutes and 70 % of the preparation is released in 3 minutes

TRUE

35

True or False about Validol. It is used in cases of angina pectoris, motion sickness, nausea, vomiting when seasick or airsick and headaches due to taking nitrates

TRUE

36

Which antianginal agents is the specific bradycardic drug

Alinidine

37

True or False about Alinidine. Bradycardic drugs have a moderate reflex and vascular dilative action caused by the stimulation of sensitive nerve endings

FALSE

38

True or False about Alinidine. The predominant effect of bradycardic drugs is a decrease in heart rate without significant changes in arterial pressure

TRUE

39

True or False about Alinidine. The protective effect of bradycardic drugs is likely due to a reduced O2 demand

TRUE

40

True or False about Alinidine. Specific bradycardic agents are used in the management of a wide range of cardiovascular disorders, including sinus tachyarrhythmias and angina pectoris

TRUE

41

True or False about Dipyridamole. Dipyridamole is an agent that blocks the reabsorption and breakdown of adenosine that results in an increase of endogenous adenosine and vasodilatation

TRUE

42

True or False about Dipyridamole. The drug causes relative hypoperfusion of myocardial regions served by coronary arteries with haemodynamically significant stenoses

TRUE

43

True or False about Dipyridamole. Dipyridamole is a platelet aggregation inhibitor

TRUE

44

Which antianginal agents is a potassium channel opener

Minoxidil

45

True or False about potassium channel openers. These agents decrease transmembrane calcium current associated in a smooth muscle with long-lasting relaxation and in a cardiac muscle with a reduction in contractility

FALSE

46

True or False about potassium channel openers. These agents has a moderate reflex and vascular dilative action caused by the stimulation of sensitive nerve endings

FALSE

47

True or False about potassium channel openers. Beneficial effects of these agents are related primarily to their hemodynamic effects – decreased heart rate, blood pressure, and contractility – which decrease myocardial oxygen requirements at rest and during exercise

FALSE

48

True or False about potassium channel openers. These agents increase the permeability of K channels, probably ATP-dependent K channels, that results in stabilizing the membrane potential of excitable cells near the resting potential

TRUE

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