ORGANOTROPIC AGENTS - Drugs used in disorders of coagulation Flashcards Preview

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Flashcards in ORGANOTROPIC AGENTS - Drugs used in disorders of coagulation Deck (27):
1

Physiologic reactions are involved in the control of bleeding

- Platelet adhesion reaction
- Platelet release reaction
- Triggering of the coagulation process

2

Physiologic reactions that are not involved in the control of bleeding

Activation of the antifibrinolytic system

3

Which substances is synthesized within vessel walls and inhibits thrombogenesis?

Prostacyclin (PGI2)

4

The following groups of drugs are for thrombosis treatment

- Anticoagulant drugs
- Fibrinolitic drugs
- Antiplatelet drugs

5

The following group of drugs are not for thrombosis treatment

Antifibrinolitic drugs

6

Drug belonging to anticoagulants of direct action

Heparin

7

Which drugs has low-molecular weight?

Enoxaparin

8

Indicate the drug belonging to antagonists of heparin

Protamine sulfate

9

Drug used as an oral anticoagulant

Dicumarol

10

Drugs are indirect acting anticoagulants

- Dicumarol
- Warfarin
- Phenindione

11

Drugs that are not indirect acting anticoagulants

Dalteparin

12

Which drugs belongs to coumarin derivatives?

Warfarin

13

True or False. Heparin is effective when administred orally.

FALSE

14

Drugs that are antiplatelet agents

- Aspirin
- Ticlopidine
- Clopidogrel

15

Drugs that are not antiplatelet agents

Urokinase

16

True or False. The use of heparin is recommended for treatment of deep venous thrombosis.

TRUE

17

Mechanism of aspirin action is

Inhibits COX and thus thromboxane synthesis

18

Which doses of Aspirin may be more effective in inhibiting Tromboxane A2? (Low or High)

LOW

19

Which drugs is an inhibitor of platelet glycoprotein IIb/IIIa receptors?

Abciximab

20

True or False. Ticlopidine is an inhibitor of ADP-induced platelet aggregation.

TRUE

21

Which drugs is fiibrinolytic?

Streptokinase

22

True or False. Mechanism of urokinase action is an inhibition of Thromboxane A2.

FALSE

23

Fibrinolytic drugs are used for

- Central deep venous thrombosis
- Multiple pulmonary emboli
- Acute myocardial infarction

24

Fibrinolytic drugs are NOT used for

Heart failure

25

Indicate the drug belonging to fibrinoliytic inhibitors

Aminocapronic acid

26

Aminocapronic acid is a drug of choice for treatment of

Bleeding from fibrinolytic therapy

27

True or False. Tranexamic acid is an analog of aminocapronic acid.

TRUE

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