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Flashcards in osteoporosis Deck (27):
1

General risk factors for osteoperosis

-White and asians-high risk factor
-Female
-lower weight
-age (anyone over 80 has high risk of hip fracture)
-genetics

2

Hypogonadal causes of osteoperosis

Hypogonadal:
-early menopause/late menarche
-androgen insensitivity
-overtraining females


3

what are some mineral deficiency for osteoperosis

calcium, VIt D, magnesium

4

what tests would you order for osteoporoosis

CBC
Chem 7,--electrolytes and calcium
LFT--liver function
ESR--autoimmune disorder

Ca, VIt D Mg levels

5

DEXA scan

used to diagnose osteoperosis

Measures BMD(bone mass density)
measuring hip and back

6

T score

compares pt value to same sex healthy 30 y/o. THIS IS THE SCORE THAT COUNTS




7

which score do you base your treatment off

T score
this will determine if you are osteopenic or osteoperitic

8

Z score

compares pt to person with same age, sex and race, this number can fluctuate thats why we dont use it to compare

9

T score of 0-1

normal

10

T score 1-2.5

osteopenia--consider treatment

risk of hip fx 20-50%

11

T score <2.5

osteoporosis; treatment needed

12

who should be tested for osteoperosis

-ALL women over 65
-Any postmenopausal women with 1 or more risk factors
-disease/meds put one at risk
-low trauma fractures
-Positive screening

13

2ndary causes of Meds

Meds:
-steroids
-proton pump inhibitors
-SSRI
-depo-provera shots (only2 yrs used--Birth control)

14

major lifestyle risk for osteoperosis

DIET if low caLCIUM and protein, and soda

15

what is the Peak bone mass age?

30-40s

16

if given too much calcium, where do the calcium go?

it goes into the vessels and sits in vessels.

17

what do you need in your diet for building good bone density

vitamin C & D
AVOID soda (has phosphorus)
Avoid caffeine
Limit Na (pushes out Ca)
TOO much soy/too much or too little protein

18

Treatment options

Ca/Vit D- limited effects
Biphosphonates** (most common)
HRT and SERMS
-hormone replacement therapy
RANKL
Parathyroid

19

what is the main treatment of choice for osteoporosis

biphosphonates

20

how does Vitamin D help?

helps with other med be more effective, and decrease risk of fracture

21

Biophophonate tx

block osteoclast(prevent reabsorption). NOT fast acting

22

HRT--hormone replacement therapy

and what are some adverse effects for HRT

prevents bone reasborption (breakdown). have to balance with risk of HRT in women

need to give men testosterone--only helped those over 65 yrs old who are low

prob w/ breast cancer, stroke, CAD, so not 1st linfe

23

Raloxifine

positive estrogen effects on bone, blocks it in breasts and uterus

used to prevent recurrance of as Breast cancer, NOT as effective as HRT

24

What drug is used to prevent recurrance of as Breast cancer

Raloxifine

25

RANKL

considered a biologic
it's an antibody: inhibits developt and activity of osteoclast

26

what is a good way for bone stressing?

EXERCISING!!

27

Calcitonin

prevents reabsorption--not very effective, use for menopausal women who cant use estrogen