Osteoporosis Meds Flashcards Preview

Endo Pharm > Osteoporosis Meds > Flashcards

Flashcards in Osteoporosis Meds Deck (43):
1

Oh my goodness, is it spring break yet?

*I'm over this....okay back to work*

2

Evista: class

Selective estrogen receptor modulator

3

Evista: MOA

Binds to selective estrogen receptors and decreases bone resorption

4

Evista: indication

Px and Tx of osteoporosis

5

Evista: side effect

Hot flashes, peripheral edema

6

Evista: contraindication

Venous thrombosis

7

Evista: Dx-Dx

May decrease absorption of thyroid supplements

8

Do you need to cycle Evista with progestin

No you do not!

9

Fosamax: class

PO Biphosphenate

10

Fosamax: MOA

Decreases rate of bone resoprtion

11

Fosamax: indication

Px/Tx of osteoporosis in women;
Tx of osteoporosis in men;
Tx Paget's disease

12

Fosamx: side effects

Esophagitis, hypophosphatemia

13

Fosamax: contraindications

HypoCa++
Esophageal abnormalities/dysphagia
GFR below 35

14

Fosamax: Dx-Dx

NSAIDs, antacids

15

How and when do you take Fosamax?

In the AM with 6-8 oz of water

16

I just took my Fosamax, and I'm tired. I want to lay down...

But I have to stay upright for at least 30 minutes after taking it.

17

Reclast: class

IV Bisphosphenate

18

Reclast: MOA

Inhibits osteoclast activity and skeletal Ca++ release

19

Reclast: indication

Px/Tx of osteoporosis;
Tx of multiple myeloma, metastatic bone lesions, hyperCa++ of malignancy, Paget's disease

20

Reclast: side effects

Atypical Fx, ocular infection, infusion reaction

21

Reclast: contraindications

GFR below 35

22

Reclast Dx-Dx

Calcitonin, PPIs, NSAIDs

23

Osteoporosis isn't cool. Don't become osteoporotic.

My calcium window is closed, but you still have time! Save yourself! Eat dark leafy greens!....but not arugula. Arugula is gross.

24

On second thought, if you eat the arugula, there will be none left for me to eat.

Can I offer you seconds on this delicious arugula salad?

*gag*

25

Teriparatide: class

Recombinant human PTH

26

Teriparatide: MOA

Stimulates new bone formation

27

Teriparatide: indication

Severe, refractory osteoporosis

28

Teriparatide: side effects

Increased risk of bone tumors

29

Teriparatide: contraindications

Prior bone irradiation, unexplained increased ALP, open epiphysis

30

How long can you use Teriparatide?

2 years. Follow it with a bisphosphenate.

31

Calcitonin Salmon: class

Calcitonin

32

Calcitonin: MOA

Antagonizes PTH and inhibits osteoclast activity

33

Calcitonin: indication

Osteoporosis, hyperCa++, Paget's disease

34

Calcitonin: side effect

Epistaxis, flushing

35

Calcitonin goes in your...

Nose!

36

What should you remember to do with with your Calcitonin Salmon every day?

Alternate which nare you stick it in.

37

Prolia: class

RANK ligand inhibitor

38

Prolia: MOA

Human monoclonal Ab attaches to RANKL so it cannot bind to RANK receptors on osteoclast surfaces. This inhibits osteoclastogenesis and promotes osteoclast apoptosis.

39

Prolia: indication

Male and post menopausal female at high risk of Fx from osteoporosis.

40

Prolia: side efects

Increased cholesterol
Decreased bone turnover
Osteonecrosis of jaw

41

Prolia: contraindication

Immunosuppressive therapy

42

Prolia: pregnancy class

X

43

On what schedule do you take Prolia?

60mg SQ q6 months