Flashcards in Osteoporosis Meds Deck (43):
Oh my goodness, is it spring break yet?
*I'm over this....okay back to work*
Selective estrogen receptor modulator
Binds to selective estrogen receptors and decreases bone resorption
Px and Tx of osteoporosis
Evista: side effect
Hot flashes, peripheral edema
May decrease absorption of thyroid supplements
Do you need to cycle Evista with progestin
No you do not!
Decreases rate of bone resoprtion
Px/Tx of osteoporosis in women;
Tx of osteoporosis in men;
Tx Paget's disease
Fosamx: side effects
GFR below 35
How and when do you take Fosamax?
In the AM with 6-8 oz of water
I just took my Fosamax, and I'm tired. I want to lay down...
But I have to stay upright for at least 30 minutes after taking it.
Inhibits osteoclast activity and skeletal Ca++ release
Px/Tx of osteoporosis;
Tx of multiple myeloma, metastatic bone lesions, hyperCa++ of malignancy, Paget's disease
Reclast: side effects
Atypical Fx, ocular infection, infusion reaction
GFR below 35
Calcitonin, PPIs, NSAIDs
Osteoporosis isn't cool. Don't become osteoporotic.
My calcium window is closed, but you still have time! Save yourself! Eat dark leafy greens!....but not arugula. Arugula is gross.
On second thought, if you eat the arugula, there will be none left for me to eat.
Can I offer you seconds on this delicious arugula salad?
Recombinant human PTH
Stimulates new bone formation
Severe, refractory osteoporosis
Teriparatide: side effects
Increased risk of bone tumors
Prior bone irradiation, unexplained increased ALP, open epiphysis
How long can you use Teriparatide?
2 years. Follow it with a bisphosphenate.
Calcitonin Salmon: class
Antagonizes PTH and inhibits osteoclast activity
Osteoporosis, hyperCa++, Paget's disease
Calcitonin: side effect
Calcitonin goes in your...
What should you remember to do with with your Calcitonin Salmon every day?
Alternate which nare you stick it in.
RANK ligand inhibitor
Human monoclonal Ab attaches to RANKL so it cannot bind to RANK receptors on osteoclast surfaces. This inhibits osteoclastogenesis and promotes osteoclast apoptosis.
Male and post menopausal female at high risk of Fx from osteoporosis.
Prolia: side efects
Decreased bone turnover
Osteonecrosis of jaw
Prolia: pregnancy class