Osteoporosis: Pathophysiology Flashcards
(7 cards)
Osteoporosis: Pathophysiology
Genetics
Age
Nutrition
Physical exercise
Medications
Comorbidity
Osteoporosis: Pathophysiology
Genetics - predisposes to low bone mass
Caucasian or Asian
Female
Family Hx
Small frame
Osteoporosis: Pathophysiology
Age - hormones (estrogen, calcitonin, and testosterone inhibit bone loss)
Post-menopause
Advanced age
Low testosterone in men
Decreased calcitonin
Osteoporosis: Pathophysiology
Nutrition - reduces nutrients needed for bone remodeling
Low
- calcium and vitamin D intake
- high phosphate intake (carbonated beverages)
- inadequate calories
Osteoporosis: Pathophysiology
Physical exercise - bones need stress for bone maintenance
Caffeine
Alcohol and smoking
Lack of exposure to sunlight
Osteoporosis: Pathophysiology
Medications - affects Ca absorption and metabolism
Corticosteroids
Antiseizures
Heparin
Thyroid hormone
Osteoporosis: Pathophysiology
Comorbidity
Anorexia nervosa
Hyperthyroidism
Malabsorption syndrome
Renal failure
