Osteosarcoma Flashcards

1
Q

What is the most common primary bone tumor of dogs?

A

Osteosarcoma

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2
Q

Which dog breeds are most commonly affected by OSA?

A

Large and giant breed dogs

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3
Q

Which part of the skeleton is most often affected by OSA in large/giant breed dogs?

A

Appendicular skeleton

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4
Q

If a small breed dog is affected by OSA, which part of the skeleton is most often affected?

A

Axial skeleton

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5
Q

Where is OSA most commonly seen?

A

Distal radius, proximal humerus, distal femur, proximal tibia (away from the elbow, close to the knee)

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6
Q

What is the onset of OSA?

A

Chronic progressive or acute after inciting incident

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7
Q

What is the most effective way to eliminate pain assoc. w/OSA?

A

Limb amputation

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8
Q

Why is limb amputation only considered a palliative treatment for OSA?

A

90% of OSA develop mets

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9
Q

What is the most common site of OSA mets?

A

Lungs

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10
Q

By how much does chemotherapy extend MST assoc. w/OSA?

A

10-12mo

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11
Q

How will OSA radiographs appear?

A

Lytic and productive lesion @ metaphysis of bone

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12
Q

If the diaphyseal region of a bone appears to be affected by OSA, what should you consider instead?

A

Mets from a primary tumor elsewhere in the body

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13
Q

Does OSA cross joints to adjacent bones?

A

No

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14
Q

How do you dx OSA?

A

FNA/biopsy of the affected bone

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15
Q

What is a complication assoc. w/FNA/biopsy of an OSA bone?

A

Pathologic fracture

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16
Q

In what % of OSA cases are pulmonary mets actually visible on radiographs?

A

Only 10% (even though 90% are metastatic)

17
Q

What liver enzyme will be elevated with OSA that is a poor prognostic indicator?

A

ALP

18
Q

What is one of the complications of a limb-sparing OSA procedure?

A

Chronic resistant infections

19
Q

What is a complication if radiation therapy is used to treat an OSA?

A

Pathological fractures

20
Q

What chemotherapy drugs are useful for OSA?

A

Platinum drugs or doxorubicin

21
Q

What other medication can help palliate pain in patients where OSA surgery is not an option?

A

Bisphosphonates

22
Q

What is the MoA of bisphosphonates?

A

Osteoclast inhibitors

23
Q

What is the MST for OSA w/amputation alone?

A

4-6mo

24
Q

What is the MST for OSA w/amputation and chemo?

A

10-12mo

25
Q

What is the MST for OSA when mets are visible in the lungs?

A

1-3mo

26
Q

What are common locations for axial OSA?

A

Mandible and maxilla, ribs, spine, pelvis

27
Q

Which axial OSA site has the best prognosis with surgery alone?

A

Mandible (70% 1yr)