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Flashcards in other anti-inflammatory Deck (27)
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1
Q

JAK inhibitors indications

A
  • rheumatoid arthritis
  • crohns disease
  • leukemias
  • alopecia
2
Q

oclacitinib indications

A

atopic dermatitis

3
Q

common cause of atopic dermatitis

A

commonly from flea bites - saliva of fleas

4
Q

JAK inhibitors pharmacological effects

A
  • antiinflammatory
  • antiallergic
  • antipruritis
5
Q

JAK inhibitors absorption

A

excellent per os absorption, 90%

6
Q

JAK inhibitors absorption with food

A

no difference

7
Q

JAK inhibitors metabolism

A

liver

8
Q

JAK inhibitors interactions

A

no interactions with other drugs

9
Q

JAK inhibitors side effects

A

no major, but sometimes causes vomiting

10
Q

lokivetmab specificity

A

highly specific

11
Q

other allergy mediated diseases

A
  • atopic dermatitis
  • cutanous food adverse reactions
  • FAD
12
Q

are antihistamines antagonists

A

no, theyre inverse agonists

13
Q

the two forms of histamine receptors

A

active and inactive

14
Q

antihistamines usage

A
  • individual differences
  • allergic diseases
  • asthma, RAO
  • anaphylactic reaction
15
Q

how many generations of antihistamines

A

2

16
Q

list 1st generation antihistamines groups

A
  • ethylenediamines
  • ethanolamines
  • phenothiazines
  • piperazines
  • others - dimetinden, cyproheptadine
17
Q

list 2nd generation antihistamines groups

A

loratadine, certirizine, levocetirizine

18
Q

ethylenediamines

A

chloropyramine, chlorpheiramine

19
Q

ethanolamines

A

diphenhydramine, dimenhydrinate

20
Q

phenothiazines

A

promethazine

21
Q

piperazines

A

hydroxyzine

22
Q

side effects of 1st generation antihistamines

A

can decr appetite, cause sedation, sleepiness, decr co-ordination

23
Q

safety of second generation

A

cannot cross blood brain barrier, v safe

24
Q

antihistamines absorption

A

good oral absorption, Cmax 2-3hrs

25
Q

2nd generation antihistamines distribution

A

ionised form and extensively albumin bound

26
Q

antihistamines metabolism

A

liver-> CYP450 inducers

27
Q

antihistamines side effects

A
  • CNS depression
  • cardiac toxicity
  • anticholinergic effect
  • appetite depression