Other antibiotics

Question 1

Vancomycin

Answer 1

Gram (+) bacteria including MRSA, penicillinase producing pneumococci and enterococci (except VRE)

Question 2

Linezolid

Answer 2

GPC including MRSA and VRE

Check susceptibility for the VRE

Question 3

Daptomycin

Answer 3

GPC including MRSA and VRE

Check susceptibility for the VRE

Question 4

Quinupristin/dalfopristin

Answer 4

GPC including MRSA and VRE

Check susceptibility for the VRE

Question 5

Quinolones

Answer 5

Enteric GnR and atypicals. Third and fourth generation increased activity vs. gram(+)

Question 6

Aminoglycosides

Answer 6

GNR. Synergy with cell wall active antibiotics (B-lactam, Vanco) vs. GPC. Decreased activity in low pH (abscess). No activity vs. anaerobes.

Question 7

Macrolides

Answer 7

GPC, some respiratory gram (-), atypicals

Question 8

TMP/SMX

Answer 8

Some enteric GNR, PCP, Nocardia, toxoplasma, most community-acquired MRSA

Question 9

Clindamycin

Answer 9

Most gram (+) (except enterococci) and anaerobes (including B. fragilis)

Question 10

Metronidazole

Answer 10

Almost all anaerobic gram(-), most anaerobic gram (+)

Question 11

Doxycycline

Answer 11

Rickettsia, Ehrlichia, Anaplasma, Chlamydia, Mycoplasma, Nocardia, lyme

Question 12

Tigecycline

Answer 12

Many GPC including MRSA and VRE; some GNR including ESBL but NOT Pseudomonas or Proteus. Approved for abdominal or skin/soft tissue infections. Check susceptibility if organism isolated.