other teratogens Flashcards Preview

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Flashcards in other teratogens Deck (14):
1

ACEi/ARB (used for kidneys of diabetic patient)

renal damage

2

Aminoglycoside (gentamicin)

ototoxicity (CN 8)

3

Fluoroquinolone (levofloxacin, ciprofloxacin)

cartilage damage of fetus/kids
fluoroquinoLONES hurt the BONES (=cartilage)

4

Tetracycline

discolored teeth of fetus/kids

5

cyclophosphamide: alkylating agent (cancer drug), inflammatory dz (SLE, psoriasis, RA)

ear + facial
limb hypoplasia (thalidAMIDE + cyclophosphAMIDE)
no digits

6

carbamazepine: seizure

neural tube defects (use folic acid before pregnancy)

7

valproATE: inhibits maternal folATE absorption (seizure)

neural tube defects (use folic acid before pregnancy)

8

phenytoin: inhibit maternal folate absorption (seizure)

fetal hydantoin syndrome
microcephaly
hypoplastic nails + distal phalanges
cardiac defect
IUGR

9

lithium: bipolar

ebstein anomaly (atrialized RV, tricuspid valve leaflets displaced lower in RV toward apex, causes hypoplastic RV + large RA, tricuspid regurg or stenosis)

10

iodine (deficiency or excess)

deficiency: hypothyroidism (cretinism)
congenital goiter

11

maternal diabetes

congenital heart defects

12

xray/CT scan

microcephaly, intellectual disability

13

alcohol

FAS:
microcephaly, holoprosencephaly (brain structures don't separate in midline, facial structures don't separate in midline (one eye)
narrow eye opening, wide set eyes
smooth philtrum, thin upper lip, cleft lip/palate

14

cocaine + smoking
non-teratogens but cause birth problems

low blood flow to baby → IUGR (low birth weight), preterm labor
fetal addiction (cocaine)

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