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Micro Exam VI > OtherSTIBacterialInfections > Flashcards

Flashcards in OtherSTIBacterialInfections Deck (31):
1

Symptoms of Urethritis in Men and Women:

Symptoms that are all common with gonorrhea and chlamydia. **MUST TEST for C and G if patient has urethritis**

2

Most common cause of Non-gonococcal Urethritis (NGU):

Chlamydia

3

Other causes of Non-Gonococcal Urethritis outside of C. Trachomatis:

Mycoplasma Genitalium and Ureaplasma Urealyticum

4

Features of Mycoplasma and Ureaplasma:

SMALLEST FREE-LIVING BACTERIA **Do NOT Gram stain** **Plasma membranes contain STEROLS** **They DO NOT have a cell wall**

5

Significance of sterols in Mycoplasma and Ureaplasma:

Only bacteria that have sterols in cell membrane. They steal this from their host.

6

Implications of Mycoplasma and Ureaplasma not having a cell wall:

They are resistant to **penicillins, cephalosporins vancomycin** and other Abx that interfere with cell wall synthesis

7

Colonies of Mycoplasma have an appearance of what:

Fried Egg

8

Mycoplasma Genitalium and Mycoplasma Hominis features + NGU:

Common inhabitants of GU tract, thus makes their contribution to NGU difficult.

9

Mycoplasma Genitalium disease in men and women:

Men: NGU Female: Cervicitis/PID

10

Mycoplasma Genitalium significant feature:

RESISTANT TO DOXYCYCLINE (Which is treatment of choice for C. Trachomatis) Must use AZITHROMICIN

11

Ureaplasma common cause of:

COMMON CAUSE of NGU in MALES

12

Treatment of Acute + Recurrent Ureaplasma:

Doxycyline (also active against C. Trachomatis) **if reoccurring after treatment> possible Mycoplasma Genitalium infection treat with Azithro!**

13

Definition of NUG:

Non-gonococcal Urethritis: Infection of urethra that is NOT caused by Gonorrhoeae

14

What is a Chancroid and what is the causative agent?

Sexually transmitted genital ulcer disease caused by Haemophilus Ducreyi

15

Incidence of Chancroid in the US:

Currently: VERY LOW. Late 1980s: outbreak with sex workers and crack cocaine. More common in Africa, Asia + Caribbean)

16

**Haemophilus Ducreyi Features:

Gram (-) coccobacillus. Facultative anaerobe. Catalase (+)

17

**Haemophilus Ducreyi requirements for growth in culture

They are fastidiuous- X and V factor BOTH required for growth. Both of these factors present in heated blood agar **(chocolate agar)**

18

Symptoms of Haemophilus Ducreyi/Chancroid infection:

**ONE OR MORE PAINFUL and SOFT chancre/lesions ** **Inguinal lympadenopathy** also common and important in diagnosis.

19

Risk of Haemophilus Ducreyi Infection:

increased risk for HIV/AIDS transmission

20

Treatment of Haemophilus Ducreyi/Chancroid :

Macrolide: Azithro or Erythro

21

Making differential diagnosis of Haemophilus Ducreyi (4):

Appearance: MULTIPLE PAINFUL, SOFT genital ulcers. Negative for Syphilis. Negative HSV. Lymph adenopathy present.

22

Distinguishing Syphilis from Chancroid caused by H. Ducreyi:

Syphilis: SINGULAR, PAINLESS + INDURATED. Chancroid: MULTIPLE, PAINFUL + SOFT

23

Donovanosis/Granuloma Inguinale causative agent:

Klebsiella Granulomatis

24

*Symptoms of Donovanosis/Granuloma Inguinale:

Lesions that are: **PAINLESS, more WARTLIKE + BLEED EASILY**

25

Complications of Donovanosis/Granuloma Inguinale infection:

Can lead to significant genital damage if untreated

26

Diagnosis of Donovanosis/Granuloma Inguinale:

Appearance of Donovan bodies and ruling out other causes

27

First two differentials with a patient who is young, sexually active and has genital, anal or perianal ulcers:

Genital Herpes (HSV-2) + Syphilis

28

Chancroid and Donovanosis infections are associated with:

patients who have travelled

29

Progression of diagnosis and treatment for patient with genital ulcer disease:

1) Serologic test for syphilis or darkfield exam. 2) Diagnostic evaluation for HSV. 3) Can now test for H. Ducreyi or Klebsiella Granulomatis. Frequently must treat BEFORE test results available or there may not be a definitive diagnosis made.

30

Klebsiella granulomatis Characteristics

gram- rod, encapsulated, intracellular

31

Treatment for Klebsiella granulomatis

sulfamethoxazole, erythromycin, tetracycline, ciprofloxacin, many treatment options