Ovarian disease Flashcards Preview

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Flashcards in Ovarian disease Deck (51):
1

where do cystic follicle originate

unruptured graafian follicles or
follicles that ruptured and then sealed

2

What is luteal cyst lined with and what does it secrete? what happens when ruptured

luteinized granulosa cells
progesterone
peritoneal reaction

3

Stein-Levanthall syndrome

polycystic ovaries

4

Stein-Levanthall syndrome impact on insulin

insulin resistance

5

classification of ovarian tumors

surface epithelium
germ cells
sex cord - stroma

6

what is thought to give rise to epithelial neoplasia

cortical inclusions cysts

7

when do benign/boderline and malignant serous tumor occur

benign/boderline: younger
malignant: older

8

serous tumor gros presentation? bilateral or unilateral?

smooth-walled cyst
cyst with papillary excrescences
bilateral

9

histo for serous tumor

ciliated columnar cells
intercalted cell

10

is there invasion of boderline serous tumor

no

11

gross for malignant serous cystadenocarcinoma

more solid
invasion of ovarian stroma

12

histo for malignant serous cystadenoma

psammoma bodies

13

who gets mucinous tumors

middle age

14

which in more common mucinous or serous

serous

15

histo for mucinous benign

tall columnar cells with apical mucin
no cilia

16

what does benign mucinous resemble

cervix or intestines

17

gross for benign mucinous

multiloculated with tenacious mucous

18

histo for boderline mucinous tumor

complex glandular structures with nuclear atypia

19

what does malignant mucinous cystadenoma resemble? benign

malignant: intestinal epithelium
benign: cervical epithelium

20

what is pseudomyxomatous peritonei

extensive mucinous ascites
epithelial implants and adhesions

21

what other organ should be considered for pseudomyxomatous peritonei

appendix

22

what is an aggressive variant endometrioid adenocarcinoma

clear cell adenocarcinoma

23

what is cystadenofibroma? what is epithelium

benign fibrous stroma
- endometrioid, serous, mucinous or transitional

24

What is brenner Tumor

Epithelial component is transitional (bladder)
benign

25

epithelial tumors extend beyond ovary what can happen

peritoneal seeding with massive ascites filled with malignant cells

26

tumor marker for epithelial cells? prognosis?

CA-125
poor prognosis

27

how can you help with epithelial prevention

fallopian tube ligation
oral contraceptive therapy
BRCA mutations

28

germ cell tumors are equivalent to what in males

testicular germ cells

29

another name for germ cell tumor, benign teratomas

dermoid cyst

30

who gets germ cell tumor, benign teratomas

young women

31

germ cell tumor, benign teratomas is dervied from what

ectodermal
3 germ layers

32

chromosome for germ cell tumor, benign teratomas

46 XX

33

Immature/malignant teratomas tissue resembles what

same found in fetus or embryo

34

how is treated

chemotherapy

35

Immature/malignant teratomas gross apperace

smooth capsule
predominantly solid
necrosis/hemorrhage

36

Monodermal teratomas

struma ovarii ( thyroid)

37

Dysgerminoma? who gets it

childhood and young adults
gonadal dysgenesis

38

Dysgerminoma secretes what hormone

hCG

39

dysgerminoma histo

large vesicular cells with clear cytoplasm
well-defined cell borders
fibrous stroma containing lymphocytes

40

Dysgerminoma treatement

radiotherapy

41

what is endodermal sinus tumor

extraembryonic yolk sac structure

42

what are markers in endodermal sinus tumor

alpha-fetoprotein
alpha-1-antitrypsin

43

endodermal sinus tumor prognosis and treatement

bad
chemotherapy

44

sex cord: granulosa-theca tumor what does it secrete

secretes estrogen and inhibin

45

sex cord: granulosa-theca tumor gross

yellow due to lipid

46

sex cord: granulosa-theca tumor histo

granulosal: call-exner bodies, sheets, strands
thecal: clusters or sheets of cuboidal to polygonal cells

47

sex cord: fibroma-thecoma

fibroblast or plump spindle cells with lipid droplets

48

sex cord: fibroma-thecoma hist

increased nuclear/cytoplasmic ratio
FIBROSARCOMAS

49

sex cord: fibroma-thecoma associated with what syndrome

basal cell nevus

50

what is Meigs syndrome

pelvic pain
mass
ascites
hydrothorax

fibroma-thecoma

51

most common tumor metastatic tumor to ovary

Kruckenberg tumor