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Flashcards in Overactive bladder Deck (11):
1

Non drug treatment for OAB?

Behavioral therapies are considered 1st line such as pelvic floor muscle "kegel"

2

Which classes of meds are used to control OAB?

Anticholinergics

Beta 3 agonists

3

Which anti-muscarinic drugs have fewer CNS side effects are more selective towards the M3 receptor?

Solifenacin (Vesicare)
Darifenacin (EnableX)
Fesoterodine

4

Which anti-cholinergic must you take on an empty stomach?

Trospium XR

5

Which drug is an OROS formulation?

Ditropan XL

Once taken there might be a ghost tablet in their feces.

6

Examples of peripheral and central side effects?

Peripheral: Dry eyes, Dry mouth, urinary retention and constipation

Central: Sedation, drowsy, dizzy

7

Beta 3 agonist MOA

relaxes the detrusor muscle increasing the bladder capacity

8

Mirabegron (Myrbetriq)

Less dry mouth and can cause hypertension

Efficacy should be seen within 8 weeks

9

Which drugs is FDA approved for adults to treat Nocturia?

Noctiva (Desmopressin)

10

Noctivia dosing

Age<65 1 spray in one nostril 30 mins prior to bed (1.66mcg)

Age<65 with high risk of hyponatremia 1 spray (0.83mcg)

11

Noctivia BW, CI and monitoring?

BW: Life threatening hyponatremia

Warning: fluid retention

Monitoring: Sodium