Overlap Syndromes

Question 1

What CT Dz is assc with ... 
•	Anti- U1-RNP =
•	Anti-DNA (Smith) 
•	Anti -ANA 
•	Anti-synthetase and PM/Scl

Answer 1

• Anti- U1-RNP = MCTF
• Anti-DNA (Smith) = SLE
• Anti -ANA = SSc
• Anti-synthetase and PM/Scl = myositis

Question 2

pt has Primary biliary cirrhosis, Pulm fibrosis , PAH

what CT dz should be considered

Answer 2

scleoderma and MCTD

Question 3

puffy fingers, think

Answer 3

scleroderma and MCTD

Question 4

Muscle weakness, elevated CKs, and abnormal EMGs

Answer 4

myositis overlap

Question 5

early stage of autoimune dz that isnt clearly one specific type

Answer 5

Undifferentiated Connective Tissue Disease” (UCTD)

*most will differentiate into AICID

Question 6

prototypical overlap disease

Answer 6

MCTD

Question 7

Arthritis and ILD may precede …

Answer 7

myositis overlap

Question 8

Can be caused by exposure to vibrating tools, drugs (chemotherapy, Beta Blockers, OTC cold meds) or chemicals (vinyl chloride)

Answer 8

raynaud’s (secondary)

Question 9

The evolution of symptoms may be associated with molecular mimicry and epitope spreading.

Answer 9

MCTD