Overlap Syndromes Flashcards
1
Q
What CT Dz is assc with ... • Anti- U1-RNP = • Anti-DNA (Smith) • Anti -ANA • Anti-synthetase and PM/Scl
A
- Anti- U1-RNP = MCTF
- Anti-DNA (Smith) = SLE
- Anti -ANA = SSc
- Anti-synthetase and PM/Scl = myositis
2
Q
pt has Primary biliary cirrhosis, Pulm fibrosis , PAH
what CT dz should be considered
A
scleoderma and MCTD
3
Q
puffy fingers, think
A
scleroderma and MCTD
4
Q
Muscle weakness, elevated CKs, and abnormal EMGs
A
myositis overlap
5
Q
early stage of autoimune dz that isnt clearly one specific type
A
Undifferentiated Connective Tissue Disease” (UCTD)
*most will differentiate into AICID
6
Q
prototypical overlap disease
A
MCTD
7
Q
Arthritis and ILD may precede …
A
myositis overlap
8
Q
Can be caused by exposure to vibrating tools, drugs (chemotherapy, Beta Blockers, OTC cold meds) or chemicals (vinyl chloride)
A
raynaud’s (secondary)
9
Q
The evolution of symptoms may be associated with molecular mimicry and epitope spreading.
A
MCTD
